Depressive symptoms in youth with refractory epilepsy: Exploration of seizure, sociodemographic and cognitive factors

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-07-30 DOI:10.1016/j.yebeh.2025.110608

S.B. Brothers , C. Wolfe-Christensen , H.J. Loblein , H. Kimbley , K.E. Patrick , LN. Sepeta , K.A. McNally , J.I. Koop , R.L. Stilp , A. Ailion , K. Boyer , A.M. DeCrow , P. Espe-Pfeifer , C.M. Cooper , M. Gabriel , G.M. Berrios-Siervo , P.H. Duong , E. Hodges , D.F. Marshall , G. Gaston , J.L. Wagner

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引用次数: 0

Abstract

Introduction

Rates of depressive symptoms in children and youth with epilepsy (CYE) vary among studies, ranging from 12 to 41%. The current study examined depressive symptoms in a large, multi-site sample of CYE who completed measures of emotional and behavioral functioning as part of a pre-surgical neuropsychological evaluation.

Methods

CYE ranged in age from 5 to 18 years old, had refractory epilepsy (n = 416), and underwent neuropsychological assessment, including standardized assessment of intellectual (IQ), emotional, and behavioral functioning using caregiver-proxy. Sociodemographic (e.g., age, biological sex, race/ethnicity, insurance status, distance from hospital) and epilepsy-specific characteristics e.g., seizure type, epilepsy duration, frequency, foci, number of anti-seizure medications [ASM], and MRI findings) were also examined.

Results

Elevated levels (i.e., at-risk or clinically significant threshold) of depressive symptoms were reported in 28.9 % of CYE. Youth with temporal lobe epilepsy (TLE; 18.9 %) had significantly higher rates of depressive symptoms compared to youth with extratemporal epilepsy (11.7 %; OR = 1.73, 95 % CI [1.10, 2.73]; χ² (2) = 7.08, p = 0.029). All other sociodemographic and epilepsy-specific variables were unrelated to levels of depressive symptoms. There was no difference in level of depressive symptoms for CYE with IQ below 70 despite being more likely to be in a minority racial/ethnic group, having public insurance, and experiencing more frequent seizures.

Conclusions

CYE are at risk of comorbid depressive symptoms, especially if they have TLE. However, other seizure and sociodemographic variables did not increase risk or resilience. Depression screening during routine epilepsy care is indicated, including for those CYE with low IQ.

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青少年难治性癫痫患者的抑郁症状：癫痫发作、社会人口学和认知因素的探讨

在不同的研究中，儿童和青少年癫痫患者（CYE）出现抑郁症状的比例各不相同，从12%到41%不等。目前的研究在一个大的、多地点的CYE样本中检查了抑郁症状，这些样本完成了情绪和行为功能的测量，作为术前神经心理学评估的一部分。方法scye患者年龄在5 - 18岁，患有难治性癫痫（n = 416），并接受了神经心理学评估，包括使用照顾者代理对智力（IQ）、情绪和行为功能的标准化评估。还检查了社会人口统计学（如年龄、生理性别、种族/民族、保险状况、与医院的距离）和癫痫特异性特征（如癫痫发作类型、癫痫持续时间、频率、病灶、抗癫痫药物（ASM）数量和MRI结果）。结果28.9%的患者报告抑郁症状水平升高（即有危险或有临床意义的阈值）。青少年颞叶癫痫；18.9%)的抑郁症状发生率明显高于患有颞外癫痫的青少年(11.7%；Or = 1.73, 95% ci [1.10, 2.73]；χ2 (2) = 7.08, p = 0.029)。所有其他社会人口学和癫痫特异性变量与抑郁症状水平无关。智商低于70的青少年在抑郁症状水平上没有差异，尽管他们更有可能属于少数种族/族裔群体，拥有公共保险，并且更频繁地癫痫发作。结论scye患者有并发抑郁症状的风险，尤其是TLE患者。然而，其他癫痫发作和社会人口学变量并没有增加风险或恢复力。在常规癫痫治疗期间进行抑郁症筛查是必要的，包括那些智商低的癫痫患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.