An Integrated Pressure-Volume Loop and Pulmonary Artery Catheter

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2025-07-30 DOI:10.1016/j.jacbts.2025.101326

M. Imran Aslam MD , Aleksandra B. Gruslova PhD , Luis A. Diaz Sanmartin MS , Drew Nolen MS , James J. Elliott DVM , Alexander J. Moody PhD , Joel E. Michalek PhD , Vivek P. Jani BS, MS , Fawaz Alenezi MD, MSc , Clay Heighten MD , Jonathan W. Valvano PhD , Marc D. Feldman MD

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引用次数: 0

Abstract

An admittance technology (AT) pulmonary artery catheter was developed to measure instantaneous right ventricular (RV) pressure-volume loops. Admittance RV volumes were validated in vivo through 10 swine subjected to positive and negative hemodynamic perturbations compared with magnetic resonance imaging and ex vivo RV foam casts. Finite element analysis demonstrated the AT electric field was confined to RV blood volume. RV pressure-volume loops demonstrated anticipated changes in all hemodynamics, and end-diastolic volumes were equal to magnetic resonance imaging and foam casts (P = NS). Increasing RV end-diastolic volumes in response to acute cardiac injury were also measured (P < 0.001). We report validating an AT pulmonary artery catheter in a swine model.

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集成压力-容量环和肺动脉导管

采用导纳技术（AT）肺动脉导管测量右心室（RV）瞬时压力-容量循环。通过对10头猪进行正、负血流动力学扰动，并与磁共振成像和离体心室泡沫铸型进行比较，验证了心室体积的导纳。有限元分析表明，AT电场局限于右心室血容量。右心室压力-容积循环显示了所有血流动力学的预期变化，舒张末期容积与磁共振成像和泡沫铸型相同（P = NS）。还测量了急性心脏损伤后右心室舒张末期体积的增加(P <；0.001)。我们报告在猪模型中验证AT肺动脉导管。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.