The role of signaling lymphocytic activation molecule (SLAM) family receptors in health and disease progression: Focusing on cancer and therapy

IF 3.8 3区 医学 Q2 IMMUNOLOGY
Guhan Luo , Rong Ni , Xuanwei Huang , Yuanhui Li , Dingcun Luo
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引用次数: 0

Abstract

The SLAM family receptors are immunoglobulin superfamily receptors integral to immune cell communication and regulation. This review consolidates current knowledge on the structures and functions of SLAM family receptors members (SLAMF1–SLAMF9), emphasizing their roles within the tumor microenvironment. Notably, SLAMF7 has been extensively studied in multiple myeloma, serving as both a diagnostic marker and therapeutic target. Other SLAM family receptors are implicated in tumor immune evasion, drug resistance, and T-cell exhaustion. Emerging therapies, including monoclonal antibodies and combinations with immune checkpoint inhibitors, are evaluated. Despite promising findings, challenges such as functional redundancy and an incomplete understanding of the roles of SLAM family receptors across different cancer types persist. Ongoing research into their molecular mechanisms and clinical applications is essential for advancing effective cancer immunotherapies.
信号淋巴细胞活化分子(SLAM)家族受体在健康和疾病进展中的作用:聚焦于癌症和治疗
SLAM家族受体是免疫球蛋白超家族受体,参与免疫细胞的通讯和调节。本文综述了目前关于SLAM家族受体成员(SLAMF1-SLAMF9)的结构和功能的知识,强调了它们在肿瘤微环境中的作用。值得注意的是,SLAMF7在多发性骨髓瘤中被广泛研究,作为诊断标志物和治疗靶点。其他SLAM家族受体与肿瘤免疫逃避、耐药和t细胞衰竭有关。新兴疗法,包括单克隆抗体和联合免疫检查点抑制剂,进行了评估。尽管有了令人鼓舞的发现,但诸如功能冗余和对SLAM家族受体在不同癌症类型中的作用的不完全理解等挑战仍然存在。对其分子机制和临床应用的持续研究对于推进有效的癌症免疫治疗至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical immunology
Clinical immunology 医学-免疫学
CiteScore
12.30
自引率
1.20%
发文量
212
审稿时长
34 days
期刊介绍: Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.
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