Prognostic Value of Combined Determination of NLR, PLR, CRP and IL-6 in Peripheral Blood for Adamyumab Treatment in Patients with Ankylosing Spondylitis

IF 4.5 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

American Journal of Preventive Medicine Pub Date : 2025-07-30 DOI:10.1016/j.amepre.2025.107913

Meiqun Zhou

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引用次数: 0

Abstract

Introduction

To evaluate the predictive value of combined determination of peripheral neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) and interleukin-6 (IL-6) in the treatment of adamylizumab in patients with ankylosing spondylitis (AS).

Method

From January 2020 to May 2024, 60 patients with AS in our hospital were selected and treated with adalimumab for 12 weeks. The changes of NLR, PLR, CRP, IL-6 levels before and after treatment were compared, and the improvement of the disease was assessed by BASMI spinal activity, and the patients were divided into ineffective group (BASMI>4 points) and effective group (BASMI≤4 points). The correlation between Spearman and BASMI was analyzed, and the predictive value was analyzed by ROC curve.

Results

After treatment, the scores of NLR, PLR, CRP, IL-6 and BASMI were decreased compared with those before treatment (P<0.05). The levels of NLR, PLR, CRP and IL-6 were positively correlated with BASMI (P<0.05). Before treatment, the indexes in the ineffective group were higher than those in the effective group (P<0.05). The combined prediction AUC is 0.664.

Discussion

The combined determination of NLR, PLR, CRP and IL-6 in peripheral blood can predict the therapeutic effect of adalimumab in patients with AS.

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联合检测外周血NLR、PLR、CRP及IL-6对阿达单抗治疗强直性脊柱炎患者的预后价值

目的探讨外周血中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、c反应蛋白（CRP）和白细胞介素-6 （IL-6）联合检测对阿达单抗治疗强直性脊柱炎（AS）患者的预测价值。方法选择2020年1月~ 2024年5月我院收治的60例AS患者，给予阿达木单抗治疗12周。比较治疗前后NLR、PLR、CRP、IL-6水平的变化，并以BASMI脊柱活动评价疾病的改善情况，将患者分为无效组（BASMI≤4分）和有效组（BASMI≤4分）。分析Spearman与BASMI的相关性，并采用ROC曲线分析预测值。结果治疗后患者NLR、PLR、CRP、IL-6、BASMI评分均较治疗前降低（p < 0.05）。NLR、PLR、CRP、IL-6水平与BASMI呈正相关（P<0.05）。治疗前，无效组各项指标均高于有效组（p < 0.05）。组合预测AUC为0.664。联合检测外周血NLR、PLR、CRP和IL-6可预测阿达木单抗对AS患者的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Preventive Medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

8.60

自引率

1.80%

发文量

395

审稿时长

32 days

期刊介绍： The American Journal of Preventive Medicine is the official journal of the American College of Preventive Medicine and the Association for Prevention Teaching and Research. It publishes articles in the areas of prevention research, teaching, practice and policy. Original research is published on interventions aimed at the prevention of chronic and acute disease and the promotion of individual and community health. Of particular emphasis are papers that address the primary and secondary prevention of important clinical, behavioral and public health issues such as injury and violence, infectious disease, women''s health, smoking, sedentary behaviors and physical activity, nutrition, diabetes, obesity, and substance use disorders. Papers also address educational initiatives aimed at improving the ability of health professionals to provide effective clinical prevention and public health services. Papers on health services research pertinent to prevention and public health are also published. The journal also publishes official policy statements from the two co-sponsoring organizations, review articles, media reviews, and editorials. Finally, the journal periodically publishes supplements and special theme issues devoted to areas of current interest to the prevention community.