Aza-Friedel-Crafts cyclization of α-tetralones and α-indanones with 2-(1H-pyrro-1-yl)anilines under solvent and catalyst-free conditions: Direct access to spiroquinoxaline frameworks
Preethi N. Nair , Rahul Shingare , B.V. Subba Reddy
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引用次数: 0
Abstract
A novel solvent- and catalyst-free method has been developed for the synthesis of spiro[indene-1,4′-pyrrolo[1,2-a]quinoxaline] scaffolds by means of cyclocondensation of 2-(1H-pyrro-1-yl)anilines with 2,3-dihydro-1H-inden-1-ones under neat reaction conditions. Similarly, 3,4-dihydronaphthalen-1(2H)ones afford the corresponding spiro[naphthalene-1,4′-pyrrolo[1,2-a]quinoxaline] derivatives under these reaction conditions. The current methodology facilitates the production of a variety of spiroquinoxaline frameworks, which exhibit a wide range of biological activities. The utilization of neat reaction conditions underscores its significance in the realm of green chemistry.
期刊介绍:
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.