Neural Correlates of Inhibitory Control in Children: Evidence Using MRI and fNIRS.

IF 2.9 3区医学 Q3 CLINICAL NEUROLOGY

Brain Topography Pub Date : 2025-07-26 DOI:10.1007/s10548-025-01129-8

Leela Shah, Xin Zhou, Marissa Ann DiPiero, Jayse Merle Weaver, Corrina Frye, Steven R Kecskemeti, Ruth Y Litovsky, Andrew L Alexander, Elizabeth M Planalp, Douglas C Dean

{"title":"Neural Correlates of Inhibitory Control in Children: Evidence Using MRI and fNIRS.","authors":"Leela Shah, Xin Zhou, Marissa Ann DiPiero, Jayse Merle Weaver, Corrina Frye, Steven R Kecskemeti, Ruth Y Litovsky, Andrew L Alexander, Elizabeth M Planalp, Douglas C Dean","doi":"10.1007/s10548-025-01129-8","DOIUrl":null,"url":null,"abstract":"<p><p>Inhibitory control (IC) develops in stages from infancy through adolescence and is associated with numerous developmental disorders and learning outcomes. This study examined how neural architecture - in particular myelination - underlies brain activation patterns observed during IC tasks in a sample of 28 children aged 4-10 years old. IC was observed using reaction times during go/no-go and flanker IC tasks. Myelination was measured using quantitative longitudinal relaxation rate (R1) mapping obtained from selected white matter regions of interest (ROIs). Brain activation was defined as task-related changes in hemoglobin oxygenation as measured by functional near-infrared spectroscopy (fNIRS) averaged within ROIs. Results indicated that myelination in ROIs was higher in older children and fNIRS activation in frontal channels was significantly and positively associated with go/no-go mean reaction time. Myelination in the corona radiata and superior longitudinal fasciculus was positively associated with frontal fNIRS activation, while myelination was negatively associated with go/no-go and flanker mean reaction times across white matter ROIs. Overall, significance level notably varied across models. Independently of inhibitory control constructs, these regions may be of interest in future structure-function studies across development.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":"38 5","pages":"54"},"PeriodicalIF":2.9000,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296776/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Topography","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10548-025-01129-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Inhibitory control (IC) develops in stages from infancy through adolescence and is associated with numerous developmental disorders and learning outcomes. This study examined how neural architecture - in particular myelination - underlies brain activation patterns observed during IC tasks in a sample of 28 children aged 4-10 years old. IC was observed using reaction times during go/no-go and flanker IC tasks. Myelination was measured using quantitative longitudinal relaxation rate (R1) mapping obtained from selected white matter regions of interest (ROIs). Brain activation was defined as task-related changes in hemoglobin oxygenation as measured by functional near-infrared spectroscopy (fNIRS) averaged within ROIs. Results indicated that myelination in ROIs was higher in older children and fNIRS activation in frontal channels was significantly and positively associated with go/no-go mean reaction time. Myelination in the corona radiata and superior longitudinal fasciculus was positively associated with frontal fNIRS activation, while myelination was negatively associated with go/no-go and flanker mean reaction times across white matter ROIs. Overall, significance level notably varied across models. Independently of inhibitory control constructs, these regions may be of interest in future structure-function studies across development.

查看原文本刊更多论文

儿童抑制性控制的神经相关因素：MRI和fNIRS的证据。

抑制性控制（IC）的发展阶段从婴儿期到青春期，与许多发育障碍和学习结果有关。这项研究考察了28名4-10岁儿童在IC任务中观察到的神经结构——特别是髓鞘形成——是如何影响大脑激活模式的。通过执行/不执行和侧翼执行任务时的反应时间来观察IC。髓鞘形成的测量采用定量纵向松弛率（R1）映射，从选定的白质感兴趣区域（roi）获得。脑激活被定义为与任务相关的血红蛋白氧合变化，通过功能近红外光谱（fNIRS）在roi内平均测量。结果表明，年龄较大的儿童roi的髓鞘形成更高，额叶通道fNIRS的激活与go/no-go平均反应时间显著正相关。辐射冠和上纵束的髓鞘形成与额部fNIRS激活呈正相关，而髓鞘形成与白质roi上的go/no-go和侧侧平均反应时间负相关。总体而言，各模型的显著性水平差异显著。独立于抑制控制结构，这些区域可能会在未来的结构-功能研究中引起兴趣。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain Topography 医学-临床神经学

CiteScore

4.70

自引率

7.40%

发文量

审稿时长

3 months

期刊介绍： Brain Topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including EEG, MEG, fMRI, TMS, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Submissions combining multiple techniques are particularly encouraged, as well as reports of new and innovative methodologies.