An update on stroke and transient ischemic attack in Takayasu arteritis: a systematic review and meta-analysis.

IF 4.3 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine Pub Date : 2025-07-23 DOI:10.1016/j.jbspin.2025.105951

Xuepeng Jin, Yutong Yang, Xue Wang, Chunxiu Wang, Yi Zhao

{"title":"An update on stroke and transient ischemic attack in Takayasu arteritis: a systematic review and meta-analysis.","authors":"Xuepeng Jin, Yutong Yang, Xue Wang, Chunxiu Wang, Yi Zhao","doi":"10.1016/j.jbspin.2025.105951","DOIUrl":null,"url":null,"abstract":"Objectives: This systematic review and meta-analysis aimed to update the global prevalence of stroke and transient ischemic attack (TIA) in Takayasu arteritis (TA) patients, assess subgroup variations, and identify modifiable risk factors.Methods: Following PRISMA and MOOSE guidelines, eight databases (PubMed, EMBASE, Web of Science, Medline, and four Chinese databases) were systematically searched up to January 2025. A random-effects model was used to pool prevalence estimates, with subgroup analyses and risk factor evaluations. Heterogeneity was quantified using the I² statistic, and publication bias was assessed via funnel plots and Egger's test.Results: Thirty-four observational cohort studies (5,112 patients involved) were included. The pooled prevalence of stroke/TIA in TA patients was 10.7% (95% CI: 8.4%-13.6%), with high heterogeneity (I²=90.4%). Subgroup analyses revealed higher prevalence of stroke/TIA in males than in females (20% vs. 11%), and in European populations (13%). Ischemic stroke predominated (7%, I²=80.7%), while hemorrhagic stroke was rare (2%, I²=0%). Smoking was the sole significant modifiable risk factor (RR=1.64, 95% CI: 1.13-2.38). Stroke accounted for 21.2% of all TA-related deaths.Conclusions: TA patients face a high burden of stroke/TIA, with marked heterogeneity driven by population and methodological differences. Males and Europeans have higher prevalence of stroke/TIA. Smoking is the only modifiable risk factor in TA patients with stroke/TIA.","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":"105951"},"PeriodicalIF":4.3000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Joint Bone Spine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jbspin.2025.105951","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: This systematic review and meta-analysis aimed to update the global prevalence of stroke and transient ischemic attack (TIA) in Takayasu arteritis (TA) patients, assess subgroup variations, and identify modifiable risk factors.

Methods: Following PRISMA and MOOSE guidelines, eight databases (PubMed, EMBASE, Web of Science, Medline, and four Chinese databases) were systematically searched up to January 2025. A random-effects model was used to pool prevalence estimates, with subgroup analyses and risk factor evaluations. Heterogeneity was quantified using the I² statistic, and publication bias was assessed via funnel plots and Egger's test.

Results: Thirty-four observational cohort studies (5,112 patients involved) were included. The pooled prevalence of stroke/TIA in TA patients was 10.7% (95% CI: 8.4%-13.6%), with high heterogeneity (I²=90.4%). Subgroup analyses revealed higher prevalence of stroke/TIA in males than in females (20% vs. 11%), and in European populations (13%). Ischemic stroke predominated (7%, I²=80.7%), while hemorrhagic stroke was rare (2%, I²=0%). Smoking was the sole significant modifiable risk factor (RR=1.64, 95% CI: 1.13-2.38). Stroke accounted for 21.2% of all TA-related deaths.

Conclusions: TA patients face a high burden of stroke/TIA, with marked heterogeneity driven by population and methodological differences. Males and Europeans have higher prevalence of stroke/TIA. Smoking is the only modifiable risk factor in TA patients with stroke/TIA.

查看原文本刊更多论文

Takayasu动脉炎卒中和短暂性脑缺血发作的最新进展：系统回顾和荟萃分析。

目的：本系统综述和荟萃分析旨在更新Takayasu动脉炎（TA）患者卒中和短暂性脑缺血发作（TIA）的全球患病率，评估亚组差异，并确定可改变的危险因素。方法：按照PRISMA和MOOSE指南，系统检索截至2025年1月的8个数据库（PubMed、EMBASE、Web of Science、Medline和4个中文数据库）。随机效应模型用于汇总患病率估计，并进行亚组分析和风险因素评估。异质性采用I²统计量进行量化，发表偏倚采用漏斗图和Egger检验进行评估。结果：纳入34项观察性队列研究（5112例患者）。TA患者卒中/TIA的总患病率为10.7% (95% CI: 8.4%-13.6%)，异质性较高（I²=90.4%）。亚组分析显示，男性卒中/TIA患病率高于女性（20%对11%），在欧洲人群中（13%）。缺血性脑卒中居多（7%,I²=80.7%），出血性脑卒中少见（2%,I²=0%）。吸烟是唯一显著的可改变危险因素（RR=1.64, 95% CI: 1.13-2.38）。中风占所有ta相关死亡的21.2%。结论：TA患者面临较高的卒中/TIA负担，且由于人群和方法差异而具有明显的异质性。男性和欧洲人卒中/TIA患病率较高。吸烟是TA合并卒中/TIA患者唯一可改变的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Joint Bone Spine 医学-风湿病学

CiteScore

4.50

自引率

11.90%

发文量

184

审稿时长

25 days

期刊介绍： Bimonthly e-only international journal, Joint Bone Spine publishes in English original research articles and all the latest advances that deal with disorders affecting the joints, bones, and spine and, more generally, the entire field of rheumatology. All submitted manuscripts to the journal are subjected to rigorous peer review by international experts: under no circumstances does the journal guarantee publication before the editorial board makes its final decision. (Surgical techniques and work focusing specifically on orthopedic surgery are not within the scope of the journal.)Joint Bone Spine is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.