Diagnosis and management of diastolic dysfunction in arterial hypertension

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
P. Blanch, R. Freixa-Pamias
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引用次数: 0

Abstract

Diastolic dysfunction (DD) refers to impaired relaxation or filling of the ventricles during the diastolic phase of the cardiac cycle. Left ventricular (LV) DD is common in hypertensive individuals and is associated with increased morbidity and mortality, particularly heart failure with preserved ejection fraction (HFpEF). The pathophysiology of DD involves alterations in cardiac structure and function, neurohormonal activation, and vascular stiffness. Diagnosis is primarily based on echocardiography, and there are no specific treatment guidelines. Recently, treatments such as sodium-glucose cotransporter 2 inhibitors (SGLT2i), GLP-1 receptor agonists, and finerenone have emerged, which may offer benefits in diastolic dysfunction and HFpEF. This review aims to present the pathophysiological mechanisms of DD in hypertension (HTN), its diagnosis, and its treatment.
高血压患者舒张功能障碍的诊断与治疗。
舒张功能障碍(DD)是指在心脏周期的舒张期心室的舒张或充盈受损。左室(LV) DD在高血压患者中很常见,并与发病率和死亡率增加有关,特别是保留射血分数(HFpEF)的心力衰竭。DD的病理生理包括心脏结构和功能的改变、神经激素的激活和血管僵硬。诊断主要基于超声心动图,没有具体的治疗指南。最近,钠-葡萄糖共转运蛋白2抑制剂(SGLT2i)、GLP-1受体激动剂和芬烯酮等治疗方法已经出现,它们可能对舒张功能障碍和HFpEF有好处。本文就DD在高血压(HTN)中的病理生理机制、诊断及治疗进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hipertension y Riesgo Vascular
Hipertension y Riesgo Vascular Medicine-Internal Medicine
CiteScore
1.70
自引率
16.70%
发文量
38
审稿时长
39 days
期刊介绍: La mejor publicación para mantenerse al día en los avances de la lucha contra esta patología. Incluye artículos de Investigación, Originales, Revisiones, Casos clínicos, Aplicación práctica y Resúmenes comentados a la bibliografía internacional. Además, es la Publicación Oficial de la Sociedad española de Hipertensión-Liga Española para la Lucha contra la Hipertensión Arterial.
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