Differential Lymphocyte Infiltration Shapes Corticosteroid Efficacy in Oral Lichen Planus.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-07-25 DOI:10.1111/odi.70038

Yiwen Deng, Yufeng Wang, Junjun Chen, Guanhuan Du, Hui Yao, Lei Pan, Ting Gu, Sven Eric Niklander, Zhen Tian, Guoyao Tang

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引用次数: 0

Abstract

Background: Oral lichen planus (OLP) is a chronic, immune-mediated disorder affecting 2%-4% of the population. Corticosteroids are commonly used for treatment, but responses vary, likely due to differences in lymphocyte profiles. This study evaluated the impact of CD20+ B cells and CD38+ plasma cells on corticosteroid efficacy in OLP patients.

Patients and methods: This retrospective study included 101 patients with symptomatic, diffuse, and severe OLP. Immunohistochemical staining identified CD3+ T cells, CD20+ B cells, and CD38+ plasma cells in tissue lesions. All patients received prednisone, and outcomes were assessed using Reticulation/Erosion/Ulceration (REU) and Visual Analog Scale (VAS) scores. Statistical analyses compared treatment responses based on lymphocyte profiles.

Results: All patients showed CD3-positive T cell infiltration. Patients in the CD20- group showed significantly greater reductions in REU and VAS scores than the CD20+ group, indicating that B cell infiltration may reduce corticosteroid efficacy. Conversely, CD38+ patients exhibited greater score reductions than CD38- patients, suggesting that plasma cells may enhance responsiveness to treatment. The CD38+/CD20- group exhibited the most favorable response; the CD38-/CD20+ group had the least.

Conclusions: Infiltration by B cells and plasma cells influences corticosteroid response in OLP. B cells are associated with reduced efficacy, while plasma cells correlate with improved treatment outcomes.

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不同淋巴细胞浸润影响皮质类固醇治疗口腔扁平苔藓的疗效。

背景：口腔扁平苔藓（OLP）是一种慢性免疫介导的疾病，影响2%-4%的人群。皮质类固醇通常用于治疗，但反应不同，可能是由于淋巴细胞谱的差异。本研究评估了CD20+ B细胞和CD38+浆细胞对OLP患者皮质类固醇疗效的影响。患者和方法：本回顾性研究包括101例症状性、弥漫性和重度OLP患者。免疫组化染色在组织病变中检测到CD3+ T细胞、CD20+ B细胞和CD38+浆细胞。所有患者均接受强的松治疗，并使用网状/糜烂/溃疡（REU）和视觉模拟评分（VAS）评分评估结果。统计分析比较了基于淋巴细胞谱的治疗反应。结果：所有患者均有cd3阳性T细胞浸润。与CD20+组相比，CD20-组患者REU和VAS评分下降明显更大，提示B细胞浸润可能降低皮质类固醇的疗效。相反，CD38+患者比CD38-患者表现出更大的评分下降，表明浆细胞可能增强了对治疗的反应性。CD38+/CD20-组表现出最有利的反应；CD38-/CD20+组最小。结论：B细胞和浆细胞的浸润影响OLP的皮质类固醇反应。B细胞与降低疗效相关，而浆细胞与改善治疗结果相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.