Implementation of an early intervention strategy for post hemorrhagic ventricular dilatation in preterm infants.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-07-25 DOI:10.1038/s41372-025-02371-5

Diane Wilson, Sara Breitbart, Lee DiFonzo, Edmond Kelly, Yenge Diambomba, Dilkash Kajal, Kamini Raghuram, Sabrina Wong, Eugene Ng, Paige Church, Elizabeth Asztalos, Phyllis Glanc, Mehmet Cizmeci, Rosanna Pais, Jeffery Traubici, Lara M Leijser, Steven P Miller, Abhaya V Kulkarni, Linh G Ly

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引用次数: 0

Abstract

Objective: Evaluate earlier intervention on short- and longer-term outcomes in preterm infants with post-hemorrhagic ventricular dilatation (PHVD) born at ≤32 weeks' gestation.

Study design: Retrospective, multi-center, observational study.

Results: One hundred patients met eligibility criteria. Of 70 survivors, PHVD resolved spontaneously in 32 (46%). The 38 infants needing intervention were managed with: lumbar puncture (LP) alone (n = 23, 60%); LP and ventricular access device (VAD) only (n = 6, 16%); LP, VAD, ventricular-peritoneal shunt (n = 9, 24%). There were no differences in incidence of cerebral palsy or Bayley Scales of Infant and Toddler Development (BSID-III) composite score between the intervention and non-intervention group (p > 0.5). Neurosurgical intervention was initiated at smaller ventricle size and BSID-III scores improved significantly compared to a historical cohort with late intervention, (p < 0.05).

Conclusion: Initiation of early intervention for PHVD was feasible and was associated with improved neurodevelopmental outcomes compared to late intervention.

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早产儿出血性室性扩张早期干预策略的实施。

目的：评价早期干预对妊娠≤32周出生的出血性心室扩张（PHVD）早产儿短期和长期预后的影响。研究设计：回顾性、多中心、观察性研究。结果：100例患者符合入选标准。70例幸存者中，32例（46%）PHVD自行消退。38名需要干预的婴儿接受：单独腰椎穿刺（LP）（n = 23,60 %）；仅使用LP和心室通路装置（VAD）（n = 6,16 %）；LP， VAD，脑室-腹膜分流（n = 9, 24%）。干预组与非干预组脑瘫发生率及婴幼儿发育贝利量表（BSID-III）综合评分差异无统计学意义（p < 0.05）。与晚期干预的历史队列相比，脑室大小较小的患者开始神经外科干预，BSID-III评分显著提高。(p)结论：与晚期干预相比，早期干预PHVD是可行的，并且与改善的神经发育结果相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.