A meta-analysis on the predictive role of CRP in NEC diagnosis and prognosis.

IF 3.1 3区医学 Q1 PEDIATRICS

Italian Journal of Pediatrics Pub Date : 2025-07-26 DOI:10.1186/s13052-025-02081-w

Huanhuan Cheng, Jing Yu, Liying Dai

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引用次数: 0

Abstract

Background: This study aims to evaluate the role of C-reactive protein (CRP) in necrotizing enterocolitis (NEC) diagnosis and prognosis through a systematic review and meta-analysis.

Methods: A comprehensive search was conducted across PubMed, Cochrane Library, Embase, and Web of Science databases to identify relevant studies on CRP and NEC. Outcomes included correlations between CRP levels and NEC occurrence, surgical intervention, severity, and intestinal strictures.

Results: A total of 30 studies were included in the analysis. Data from categorical variables indicated a significant positive association between CRP and the incidence of NEC (OR: 3.5, 95% CI: 2.23-5.49), while continuous variables revealed a significant difference in CRP levels between the NEC and non-NEC groups (SMD: 2.61, 95% CI: 1.72-3.5). Elevated CRP levels were significantly correlated with an increased risk of surgery, with a notable difference in CRP levels between the surgical and non-surgical groups. CRP levels were also positively associated with the risk of NEC progression, and a significant difference was observed between the progression and non-progression groups. Besides, a significant difference in CRP levels was observed between the stricture and non-stricture groups. Subgroup analysis indicated that CRP has a higher predictive value in infants with NEC who had a gestational age greater than 28 weeks and a birth weight exceeding 1500 g.

Conclusion: CRP has significant clinical value in predicting the occurrence of NEC, disease progression, and the timing of surgical intervention.

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c反应蛋白在NEC诊断和预后预测作用的荟萃分析。

背景：本研究旨在通过系统综述和荟萃分析，评价c反应蛋白（CRP）在坏死性小肠结肠炎（NEC）诊断和预后中的作用。方法：综合检索PubMed、Cochrane Library、Embase和Web of Science数据库，确定CRP和NEC的相关研究。结果包括CRP水平与NEC发生、手术干预、严重程度和肠狭窄的相关性。结果：共纳入30项研究。分类变量的数据显示，CRP与NEC发病率之间存在显著正相关（OR: 3.5, 95% CI: 2.23-5.49），而连续变量显示，NEC组和非NEC组之间CRP水平存在显著差异（SMD: 2.61, 95% CI: 1.72-3.5）。CRP水平升高与手术风险增加显著相关，手术组和非手术组CRP水平差异显著。CRP水平也与NEC进展的风险呈正相关，并且在进展组和非进展组之间观察到显著差异。此外，在狭窄组和非狭窄组之间观察到CRP水平的显著差异。亚组分析表明，CRP对胎龄大于28周、出生体重超过1500 g的NEC患儿有较高的预测价值。结论：CRP在预测NEC的发生、病情进展及手术干预时机方面具有重要的临床价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Italian Journal of Pediatrics PEDIATRICS-

CiteScore

6.10

自引率

13.90%

发文量

192

审稿时长

6-12 weeks

期刊介绍： Italian Journal of Pediatrics is an open access peer-reviewed journal that includes all aspects of pediatric medicine. The journal also covers health service and public health research that addresses primary care issues. The journal provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field. Italian Journal of Pediatrics, which commenced in 1975 as Rivista Italiana di Pediatria, provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field.