Predictive markers of obesity and glucose metabolism dysfunction in adult common marmosets (Callithrix jacchus).

IF 3.8 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity Pub Date : 2025-07-25 DOI:10.1038/s41366-025-01841-2

Juan Pablo Arroyo, Corinna N Ross, Jessica Greig, Ricki J Colman, Suzette D Tardif, Michael L Power

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引用次数: 0

Abstract

Objective: Characterize the effects of obesity on common marmoset glucose metabolism and develop predictive markers of glucose metabolism dysfunction.

Methods: Body size, weight, lean mass, fat mass, %fat, resting energy expenditure (REE), and glycosylated hemoglobin (HbA1c) were measured on 51 adult marmosets. Physical activity was assessed using actimeter collars (n = 50). A body mass-per-length parameter (BML) was constructed. Animals were classified as without obesity or with obesity (%fat >10%) and by the age they obtained maximum weight (Maxwt). Correlation, MANOVA, and binary logistic regression were used to examine relationships between parameters; path analysis to explore directional relationships.

Results: Body fat and BML were correlated (r = 0.565, p < 0.001). Both were correlated with HbA1c (r = 0.658; r = 0.764, p < 0.001). Activity was negatively correlated with %fat and REE (r = -0.437, p = 0.002; r = -0.473, p < 0.001). REE was correlated with %fat, BML, and HbA1c (r > 0.5, p < 0.001). Marmosets with obesity were more likely to have elevated HbA1c (>5.7%; odds ratio = 8.25, p = 0.003). BML above 3.4 g/mm predicted obesity (OR = 6.25 [95% CI 1.62-24.02], p = 0.008) and high HbA1c (OR = 29.47 [95% CI 6.21-139.72], p < 0.001). Early Maxwt predicted increased fat mass (F = -0.476, p = 0.015) and high %fat (F = -0.084, p = 0.014).

Conclusion: Both %fat and BML were markers for high HbA1c. Early maximum adult weight predicts increased adiposity and risk of glucose dysfunction.

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成年普通狨猴（Callithrix jacchus）肥胖和糖代谢功能障碍的预测标志物。

目的：研究肥胖对普通狨猴糖代谢的影响，并开发糖代谢功能障碍的预测指标。方法：测定51只成年狨猴的体型、体重、瘦质量、脂肪质量、脂肪%、静息能量消耗（REE）和糖化血红蛋白（HbA1c）。使用活动计项圈评估身体活动（n = 50）。构造了身体质量-长度参数（BML）。动物被分为无肥胖和肥胖（%脂肪bb0 - 10%），并按年龄获得最大体重（Maxwt）。使用相关、方差分析和二元逻辑回归来检验参数之间的关系；路径分析，探索方向关系。结果：体脂与BML相关(r = 0.565, p 0.5, p 5.7%；优势比= 8.25,p = 0.003)。BML高于3.4 g/mm预测肥胖（OR = 6.25 [95% CI 1.62 ~ 24.02], p = 0.008）和高HbA1c (OR = 29.47 [95% CI 6.21 ~ 139.72]， p结论：%脂肪和BML均是高HbA1c的标志。早期最大成人体重预示着肥胖增加和葡萄糖功能障碍的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Obesity 医学-内分泌学与代谢

CiteScore

10.00

自引率

2.00%

发文量

221

审稿时长

3 months

期刊介绍： The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.