Upregulation of PCAT1, PCAT2, and PCAT3 LncRNAs in cervical cancer patients and their diagnostic value.

IF 1.7 Q2 MULTIDISCIPLINARY SCIENCES

BMC Research Notes Pub Date : 2025-07-25 DOI:10.1186/s13104-025-07401-1

Hadi Bazmi, Asma Alizadeh Asghari, Mahya Barzgar Jalali, Leila Rezvan, Fateme Panahi Zang Malek, Reza Safaralizadeh

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引用次数: 0

Abstract

Objective: Cervical cancer is one of the most common cancers among women. Despite advances in vaccination and screening, barriers to early detection and effective treatment remain. lncRNAs play an important role in cancer progression and therapeutic responses. New lncRNAs such as PCAT1, PCAT2, and PCAT3 have shown oncogenic activities in multiple cancers, but their role in cervical cancer is not understood. This study investigated the expression patterns of PCAT1, PCAT2, and PCAT3 in cervical cancer to evaluate their use as diagnostic markers and therapeutic targets.

Results: The expression level of PCAT1, PCAT2, and PCAT3 was significantly (P value < 0.05) higher in tumor tissues.ROC analysis showed a moderate diagnostic biomarker value for PCAT1 (AUC 0.79, sensitivity 79%, specificity 69%). Spearman's analysis showed a positive correlation between PCAT1-PCAT2 and PCAT1-PCAT3. PCAT1, PCAT2, and PCAT3 lncRNAs significantly increase in cervical cancerous tissues and may play a role as novel oncogenes. Their use as clinical diagnostic markers requires further studies.

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宫颈癌患者PCAT1、PCAT2、PCAT3 lncrna表达上调及其诊断价值

目的：宫颈癌是女性中最常见的癌症之一。尽管在疫苗接种和筛查方面取得了进展，但早期发现和有效治疗的障碍仍然存在。lncrna在癌症进展和治疗反应中发挥重要作用。新的lncrna如PCAT1、PCAT2和PCAT3在多种癌症中显示出致癌活性，但它们在宫颈癌中的作用尚不清楚。本研究探讨了PCAT1、PCAT2和PCAT3在宫颈癌中的表达模式，以评估其作为诊断标志物和治疗靶点的价值。结果：PCAT1、PCAT2、PCAT3的表达水平显著高于对照组(P值

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Research Notes Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

3.60

自引率

0.00%

发文量

363

审稿时长

15 weeks

期刊介绍： BMC Research Notes publishes scientifically valid research outputs that cannot be considered as full research or methodology articles. We support the research community across all scientific and clinical disciplines by providing an open access forum for sharing data and useful information; this includes, but is not limited to, updates to previous work, additions to established methods, short publications, null results, research proposals and data management plans.