Evaluation of the economic burden of carbapenem-resistant Enterobacteriaceae nosocomial infection in intensive care unit patients: A propensity score--adjusted analysis.

IF 2.4 3区医学 Q2 INFECTIOUS DISEASES

American journal of infection control Pub Date : 2025-07-24 DOI:10.1016/j.ajic.2025.07.007

Zongke Long, Shengjia Xu, Jian Liu, Bingyan Zhang, Peiyun Zhou, Fang Xue, Lan Gao, Siya Meng, Xiaorong Luan

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引用次数: 0

Abstract

Background: This study examines the impact of carbapenem-resistant Enterobacteriaceae (CRE) infections relative to carbapenem-sensitive Enterobacteriaceae (CSE) on the length of stay and hospitalization costs of patients in the intensive care unit (ICU).

Methods: We retrospectively analyzed patients who developed nosocomial infections with Enterobacteriaceae bacteria while admitted to the ICU of a university-affiliated general hospital in China between January 2022 and December 2024. Using propensity score matching (PSM), matched 1:1 to analyze their length of stay and hospitalization costs. A generalized linear model (GLM) was used to calculate the odds ratio (OR) of matching them.

Results: Of the 346 patients, 90 had CRE infections, and 256 had CSE infections. After PSM, patients in the CRE group had an extended hospital stay (8 days longer, P < .001) and higher hospital costs (26,842.44 Yuan more, P = .039). The GLM analysis showed that CRE-infected patients had significantly higher hospital stays (OR: 1.456, 95% CI: 1.176-1.806) and hospital costs (OR: 1.303, 95% CI: 1.107-1.536).

Conclusions: CRE infections in ICU patients are associated with longer hospital stays and increased hospitalization costs. Clinicians should strengthen infection prevention and control measures to reduce the incidence of CRE infections and conserve medical resources.

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重症监护病房患者碳青霉烯耐药肠杆菌科医院感染的经济负担评估：倾向评分调整分析。

背景：本研究探讨了碳青霉烯耐药肠杆菌科（CRE）感染相对于碳青霉烯敏感肠杆菌科（CSE）对重症监护病房（ICU）患者住院时间和住院费用的影响。方法：回顾性分析2022年1月至2024年12月在中国某大学附属综合医院ICU住院期间发生肠杆菌科细菌院内感染的患者。采用倾向得分匹配（PSM），匹配1:1，分析其住院时间和住院费用。采用广义线性模型（GLM）计算两者匹配的比值比（OR）。结果：346例患者中，CRE感染90例，CSE感染256例。呼吸道感染在两组中最常见，肺炎克雷伯氏菌是主要病原体。PSM匹配后，CRE组患者住院时间延长（8d）。结论：ICU患者CRE感染与住院时间延长、住院费用增加有关，加重了患者的经济负担。临床医生应加强感染防控措施，降低CRE感染发生率，节约医疗资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of infection control 医学-传染病学

CiteScore

7.40

自引率

4.10%

发文量

479

审稿时长

24 days

期刊介绍： AJIC covers key topics and issues in infection control and epidemiology. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer-reviewed articles covering clinical topics as well as original research. As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC)