Ethnic differences in coronary plaque burden and characteristics: A matched CCTA cohort study of South Asians and non-Hispanic Whites.

IF 5.7 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Atherosclerosis Pub Date : 2025-10-01 Epub Date: 2025-07-19 DOI:10.1016/j.atherosclerosis.2025.120455

Venkat Sanjay Manubolu, April Kinninger, Suvasini Lakshmanan, Suraj Dahal, Keishi Ichikawa, Dhiran Verghese, Luay Alalawi, Jairo Aldana, Shriraj Susarla, Hoon J Seok, Chris Dailing, Sion K Roy, Anand Rohatgi, James P Earls, Matthew J Budoff

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引用次数: 0

Abstract

Background/aims: South Asians (SA) experience a significantly higher incidence of atherosclerotic cardiovascular disease (CVD) events compared to non-Hispanic whites (NHW). However, detailed plaque characteristics in SA, particularly assessed through quantitative coronary plaque analysis using coronary computed tomography angiography (CCTA), remain under-investigated. This study aimed to compare the characteristics of coronary plaque burden between SA and NHW using CCTA.

Methods: In this cross-sectional study, we identified 165 SA subjects at our institution who underwent CCTA and matched them 1:1 for age, sex, BMI and diabetes mellitus with NHW. Quantitative coronary plaque analysis was reported by plaque subtypes in percent atheroma volume (PAV) and absolute plaque volumes. Kruskall-Wallis test was used to analyze the plaque volumes and PAV between the matched cohorts.

Results: A total of 330 subjects (mean age: 65 ± 9.9 years; 74 % male; 32 % with diabetes) formed the study population. SA had higher total plaque PAV (median [IQR]: 11.9 [4.4, 22.0] vs. 6.2 [2.4, 14.2]), NCP PAV (5.1 [3.2, 8.1] vs. 3.8 [1.8, 6.5]), and calcified plaque PAV (4.9 [1.4, 12.7] vs. 2.4 [0.3, 7.5]) than NHW (p < 0.0001). Differences were significant for those under 55 and 65 years but not in those ≥65, except for calcified plaque PAV when stratified by age.

Conclusion: Younger SA (<55 years) exhibited higher total, non-calcified, and calcified plaque burden compared to NHW, suggesting earlier CAD risk. CCTA may aid early detection and support aggressive prevention strategies in this high-risk population.

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冠状动脉斑块负担和特征的种族差异：南亚人和非西班牙裔白人的匹配CCTA队列研究。

背景/目的：与非西班牙裔白人（NHW）相比，南亚人（SA）经历了显著更高的动脉粥样硬化性心血管疾病（CVD）事件发生率。然而，详细的斑块特征，特别是通过冠状动脉计算机断层血管造影（CCTA）定量冠状动脉斑块分析评估，仍有待研究。本研究旨在通过CCTA比较SA和NHW患者冠状动脉斑块负荷的特点。方法：在这项横断面研究中，我们在我们的机构中确定了165名接受CCTA的SA受试者，并根据年龄、性别、BMI和糖尿病与NHW进行1:1的匹配。定量的冠状动脉斑块分析报告了斑块亚型在百分比粥样斑块体积（PAV）和绝对斑块体积。使用Kruskall-Wallis试验分析匹配队列之间的斑块体积和PAV。结果：共纳入330例受试者，平均年龄65±9.9岁；男性占74%；32%的糖尿病患者)构成了研究人群。SA总斑块PAV（中位数[IQR]: 11.9[4.4, 22.0]对6.2[2.4,14.2]）、NCP PAV（5.1[3.2, 8.1]对3.8[1.8,6.5]）和钙化斑块PAV（4.9[1.4, 12.7]对2.4[0.3,7.5]）均高于NHW (p)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atherosclerosis 医学-外周血管病

CiteScore

9.80

自引率

3.80%

发文量

1269

审稿时长

36 days

期刊介绍： Atherosclerosis has an open access mirror journal Atherosclerosis: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Atherosclerosis brings together, from all sources, papers concerned with investigation on atherosclerosis, its risk factors and clinical manifestations. Atherosclerosis covers basic and translational, clinical and population research approaches to arterial and vascular biology and disease, as well as their risk factors including: disturbances of lipid and lipoprotein metabolism, diabetes and hypertension, thrombosis, and inflammation. The Editors are interested in original or review papers dealing with the pathogenesis, environmental, genetic and epigenetic basis, diagnosis or treatment of atherosclerosis and related diseases as well as their risk factors.