Atomically Precise Octanuclear Cu(II) Complex With [Ph2PO2]− for Chemodynamic Therapy

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2025-07-28 DOI:10.1002/aoc.70332

Di-Yu Yang, Qiong-Qiong Zhong, Cheng-Fei Chen, Di Yao, Hai-Ye Li, Fu-Ping Huang

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Abstract

In recent research, an atomically precise Cu(II) complex (Cu8) consisting of eight copper atoms has been successfully synthesized. This complex exhibits a unique capability to catalyze a Fenton-like reaction within the tumor microenvironment (TME), which is characterized by overexpressed hydrogen peroxide. The Cu(II) complex Cu8 exploits this condition to generate highly cytotoxic hydroxyl radicals. These radicals are extremely effective in inducing programmed cell death or apoptosis in HeLa cells, a type of cervical cancer cell, and additionally cause significant damage to the mitochondria (the powerhouses of the cell). Due to these properties, the complex functions as a potent chemodynamic therapy (CDT) agent, demonstrating promising antitumor potential. The precise coordination of the [Ph₂PO₂]⁻ ligand within the complex is critical to its effectiveness in catalyzing the Fenton-like reaction, thereby enabling its therapeutic application in chemodynamic therapy.

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原子精确的八核Cu（II）配合物与[Ph2PO2]−用于化学动力学治疗

在最近的研究中，成功地合成了由8个铜原子组成的原子精确的Cu（II）配合物（Cu8）。该复合物在肿瘤微环境（TME）中表现出独特的催化芬顿样反应的能力，其特征是过氧化氢过表达。Cu（II）配合物Cu8利用这种条件产生高细胞毒性的羟基自由基。这些自由基在诱导HeLa细胞（一种宫颈癌细胞）的程序性细胞死亡或凋亡方面非常有效，并且对线粒体（细胞的动力）造成严重损害。由于这些特性，该复合物作为一种有效的化学动力疗法（CDT）药物，显示出有希望的抗肿瘤潜力。[Ph2PO2]−配体在复合物内的精确配合对其催化芬顿样反应的有效性至关重要，从而使其在化学动力学治疗中的应用成为可能。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.