Complications of diverticulosis, frequency and risk factors: Results from a large database with long-term follow-up

IF 2.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Colorectal Disease Pub Date : 2025-07-28 DOI:10.1111/codi.70185

Jabir Elkrinawi, Roba Ganayem, Sarah Weissmann, Waleed Alamour, Zlata Lerner, Osama Alamour, Abed Abu Ganim, Naim Abu-Freha

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引用次数: 0

Abstract

Background

Diverticulosis of the Colon (DC) is a common finding at colonoscopies.

Aims

We aimed to investigate the differences between complicated DC (CDC) and uncomplicated DC (UDC) and to explore the risk factors for CDC.

Methods

We analysed data from a cohort of 149,094 patients, including 123,024 UDC patients and 26,070 CDC patients. Demographics, comorbidities and clinical outcomes were compared.

Results

Patients with CDC were significantly younger (64.3 ± 15 years vs. 67.5 ± 12.7 years), 55.6% vs. 53.2% females and 8.9% of Arab ethnicity. Smoking was more prevalent in the CDC group (28.2% vs. 26.1%). Diabetes Mellitus and obesity were less prevalent in the CDC group. Treatment with statins (29.2% vs. 40.4%) was also less commonly used in the CDC group. In the multivariate analysis, female gender and smoking were found to be risk factors for CDC (OR 1.215 and OR 1.150, p < 0.001, respectively). Age, Diabetes Mellitus, Obesity, Acetylsalicylic Acid and statin treatment were found to be protective against complications.

Conclusions

Young age, female sex and smoking were associated with complicated diverticulosis, and uncomplicated diverticulosis seems to be protected by specific diseases. Understanding these differences may help guide risk stratification and improve management strategies for diverticulosis.

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憩室病的并发症，频率和危险因素：来自长期随访的大型数据库的结果

背景结肠憩室病（DC）是结肠镜检查的常见发现。目的探讨复杂性DC （CDC）与非复杂性DC （UDC）的差异，探讨CDC的危险因素。方法我们分析了149094例患者的队列数据，其中包括123024例UDC患者和26070例CDC患者。比较人口统计学、合并症和临床结果。结果CDC患者明显年轻化（64.3±15岁vs. 67.5±12.7岁），女性55.6% vs. 53.2%，阿拉伯裔8.9%。吸烟在CDC组更为普遍（28.2%比26.1%）。在CDC组中，糖尿病和肥胖症发病率较低。他汀类药物治疗（29.2% vs 40.4%）在CDC组中也较少使用。在多因素分析中，女性和吸烟是CDC的危险因素（OR分别为1.215和1.150,p < 0.001）。年龄、糖尿病、肥胖、乙酰水杨酸和他汀类药物治疗对并发症有保护作用。结论年轻、女性和吸烟与复杂性憩室病有关，而非复杂性憩室病似乎有特定疾病的保护作用。了解这些差异可能有助于指导风险分层和改善憩室病的管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colorectal Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

11.80%

发文量

406

审稿时长

1.5 months

期刊介绍： Diseases of the colon and rectum are common and offer a number of exciting challenges. Clinical, diagnostic and basic science research is expanding rapidly. There is increasing demand from purchasers of health care and patients for clinicians to keep abreast of the latest research and developments, and to translate these into routine practice. Technological advances in diagnosis, surgical technique, new pharmaceuticals, molecular genetics and other basic sciences have transformed many aspects of how these diseases are managed. Such progress will accelerate. Colorectal Disease offers a real benefit to subscribers and authors. It is first and foremost a vehicle for publishing original research relating to the demanding, rapidly expanding field of colorectal diseases. Essential for surgeons, pathologists, oncologists, gastroenterologists and health professionals caring for patients with a disease of the lower GI tract, Colorectal Disease furthers education and inter-professional development by including regular review articles and discussions of current controversies. Note that the journal does not usually accept paediatric surgical papers.