Biomaterial-Assisted Senescence-Targeting Treatment Strategy for Central Nervous System Injury.

Abstract

Central nervous system (CNS) injury triggers a series of complex pathophysiological reactions, including neuroinflammation, oxidative stress, and DNA damage. These factors play key roles in inducing cellular senescence, thereby disrupting the balance of the microenvironment and seriously hindering tissue regeneration and repair processes. Thus, targeting cellular senescence presents a promising target for the treatment of CNS injuries. In this review, we summarized multiple potential strategies targeting senescence, including the regulation of neuroinflammation, apoptosis, oxidative stress, mitochondrial dysfunction, DNA damage, and stem cell supplementation. Furthermore, we discussed representative biomaterials with functional potential to target cellular senescence and their applications in promoting repair and regeneration in CNS injuries.