Plasma Metabolites Link Non-Communicable Diseases to Increased White Matter Hyperintensities

IF 5 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2025-07-28 DOI:10.1111/cns.70507

Nan Wang, Baoshan Qiu, Weiqi Chen, Yuesong Pan, Yilong Wang

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引用次数: 0

Abstract

Aims

Cerebral small vessel disease (CSVD) and non-communicable diseases (NCDs) are major global health burdens. White matter hyperintensities (WMH) are a key imaging feature of CSVD, but the relationship between WMH and NCDs, especially the role of plasma metabolites in this association, remains unclear. This study aims to elucidate this link.

Methods

This study included participants with WMH from the UK Biobank cohort and examined the prevalence of 29 common NCDs in this population. General linear regression was used to analyze the association between NCDs and WMH. Propensity score matching and elastic net regression identified plasma metabolites associated with NCDs. Mediation analysis was conducted to explore the role of these metabolites in the association between NCDs and WMH.

Results

A total of 44,630 participants were included, of whom 47.0% were male. Approximately one-third of the participants had NCDs, with the most common being hypertension, dyslipidemia, and asthma. Compared to those without NCDs, the WMH volume in individuals with one or more comorbid NCDs was significantly increased by 18.43% to 68.15%. During a median follow-up of 9.5 years, individuals with hypertension, obstructive sleep apnea, and hypertension combined with coronary ischemic heart disease had significantly larger WMH volumes compared to those without NCDs, with increases of 30.81%, 36.44%, and 36.75%, respectively. Further analysis revealed that plasma metabolites associated with NCDs mediated this risk.

Conclusions

This study elucidated the association between WMH and NCDs, showing that common NCDs significantly increase WMH volume. Plasma metabolites associated with NCDs mediate this risk. This provides new insights into preventing WMH progression in individuals.

Abstract Image

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血浆代谢物将非传染性疾病与白质高强度增加联系起来

目的脑血管病（CSVD）和非传染性疾病（NCDs）是全球主要的健康负担。白质高信号（WMH）是心血管疾病的一个关键影像学特征，但WMH与非传染性疾病之间的关系，尤其是血浆代谢物在这一关联中的作用尚不清楚。本研究旨在阐明这一联系。方法本研究纳入了来自英国生物银行队列的WMH患者，并检查了该人群中29种常见非传染性疾病的患病率。采用一般线性回归分析非传染性疾病与WMH之间的关系。倾向评分匹配和弹性净回归确定了与非传染性疾病相关的血浆代谢物。进行了中介分析，以探讨这些代谢物在非传染性疾病和WMH之间的关联中的作用。结果共纳入44,630名参与者，其中47.0%为男性。大约三分之一的参与者患有非传染性疾病，最常见的是高血压、血脂异常和哮喘。与无非传染性疾病人群相比，患有一种或多种共病非传染性疾病人群的WMH量显著增加18.43%至68.15%。在中位9.5年的随访期间，高血压、阻塞性睡眠呼吸暂停和高血压合并冠心病患者的WMH体积明显大于非传染性疾病患者，分别增加了30.81%、36.44%和36.75%。进一步分析显示，与非传染性疾病相关的血浆代谢物介导了这一风险。结论本研究阐明了WMH与非传染性疾病之间的关联，表明常见的非传染性疾病显著增加了WMH的体积。与非传染性疾病相关的血浆代谢物介导了这种风险。这为预防个人WMH进展提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.