Multifunctional gold nanoclusters as next-generation theranostic platforms for disease management

IF 6.4 2区医学 Q1 PHARMACOLOGY & PHARMACY

International Journal of Pharmaceutics: X Pub Date : 2025-07-21 DOI:10.1016/j.ijpx.2025.100361

Yan Sun , Yining Chen , Xiaoyang Hu , Ai Liu , Lizhong He , Afang Dai , Tiansheng Wei , Shoucui Wang , Zibao Gan

引用次数: 0

Abstract

Gold nanoclusters (GNCs), typically consisting of a few to a few hundred gold atoms with a core size below 3 nm, have emerged as revolutionary nanomaterials due to their diverse and tunable molecule-like properties, high photostability, and excellent biocompatibility. These advantages establish GNCs as next-generation theranostic platforms for precise nanomedicine applications. In this review, we summarize the typical synthesis methodologies, focus on their latest cutting-edge applications in disease management, including bioimaging, sensing, drug delivery, cancer, and other diseases. Finally, we discuss the challenges and opportunities associated with GNCs as theranostic agents. It is envisioned that this review aims to guide the rational design of GNC-based smart platforms and stimulate interdisciplinary innovation in personalized medicine.

Abstract Image

查看原文本刊更多论文

多功能金纳米团簇作为新一代疾病治疗平台

金纳米团簇（GNCs）通常由几个到几百个金原子组成，核心尺寸小于3nm，由于其多样化和可调的分子样特性，高光稳定性和优异的生物相容性，已成为革命性的纳米材料。这些优势使GNCs成为精确纳米医学应用的下一代治疗平台。在本文中，我们总结了典型的合成方法，重点介绍了它们在疾病管理中的最新前沿应用，包括生物成像、传感、药物传递、癌症和其他疾病。最后，我们讨论了GNCs作为治疗药物的挑战和机遇。旨在指导基于gnc的智能平台的合理设计，激发个性化医疗的跨学科创新。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

24 days

期刊介绍： International Journal of Pharmaceutics: X offers authors with high-quality research who want to publish in a gold open access journal the opportunity to make their work immediately, permanently, and freely accessible. International Journal of Pharmaceutics: X authors will pay an article publishing charge (APC), have a choice of license options, and retain copyright. Please check the APC here. The journal is indexed in SCOPUS, PUBMED, PMC and DOAJ. The International Journal of Pharmaceutics is the second most cited journal in the "Pharmacy & Pharmacology" category out of 358 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.