Synthesis of phosphoryl imidazo[1,2-a]pyridines enabled by a molecular I2 catalyzed Gröbcke-Blackburn-Bienaymé reaction

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-07-25 DOI:10.1016/j.tet.2025.134864

Wen Qin , Lingmeng Xie , Jingru Zou , Xingang Xie , Xing Huo

引用次数: 0

Abstract

Phosphoryl-substituted imidazo[1,2-a]pyridines were efficiently synthesized via iodine-catalyzed Groebke-Blackburn-Bienaymé (GBB) three-component reaction, using phosphonate/phosphine oxide-substituted aldehydes, 2-aminopyridines and isocyanides. This reaction proceeds in green solvent ethanol, with yields up to 89 %, and advantages of mild conditions, broad compatibility and high atom economy. Derivative transformations and multigram scalability highlight its utility.

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用分子I2催化Gröbcke-Blackburn-Bienaymé反应合成磷酰咪唑[1,2-a]吡啶

以膦酸盐/氧化膦取代醛、2-氨基吡啶和异氰化物为原料，通过碘催化groebke - blackburn - bienaym (GBB)三组分反应，高效合成了磷基取代咪唑[1,2-a]吡啶。该反应在绿色溶剂乙醇中进行，收率高达89%，具有条件温和、相容性广、原子经济性高等优点。导数变换和多图可扩展性突出了它的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.