Tinocrinoids A-D, clerodane diterpenoids from Tinospora crispa and structural revision of related diterpenoid

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-07-21 DOI:10.1016/j.tet.2025.134851

Ming-Jie Huang, Yi-Ke Yin, Yi-Fei Zhang, Jie Bao, Jun-Sheng Zhang, Hua Zhang

引用次数: 0

Abstract

Four new clerodane diterpenoids, tinocrinoids A−D (2−5), were isolated from the leaves of Tinospora crispa. Compounds 3−5 represents rare clerodane diterpenoids with a C-8-O-C-12 ether bridge. The structures of the new diterpenoids were elucidated using spectral analysis in conjunction with NMR/ECD calculations and X-ray crystallography. The application of computational methods, enhanced by the DP4+ probability approach, made it possible to propose a structural revision for the known diterpenoid, tinobakisin. Evaluation of their immune modulatory effects revealed that 2 could enhance the proliferation of Jurkat T cells in a dose-dependent manner.

Abstract Image

查看原文本刊更多论文

crispa Tinospora中的tinocinooids A-D、clerodane二萜及其相关二萜的结构修正

从crispa Tinospora叶片中分离到4个新的氯烷二萜类化合物tinocrinoids A ~ D（2 ~ 5）。化合物3−5是具有C-8-O-C-12醚桥的稀有氯烷二萜。利用光谱分析、核磁共振/ECD计算和x射线晶体学对新二萜类化合物的结构进行了鉴定。利用DP4+概率方法增强的计算方法，可以对已知的二萜类化合物tinobakisin进行结构修正。对其免疫调节作用的评价显示，2能以剂量依赖的方式增强Jurkat T细胞的增殖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.