A specific bone marrow cytokine pattern in de novo acute myeloid leukemia

IF 3.8 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-07-23 DOI:10.1016/j.clim.2025.110573

Noémie Ravalet , Hélène Guermouche , Pierre Hirsch , Frédéric Picou , Vincent Flament , Caroline Deswarte , Amélie Foucault , Jenny Beaud , Emmanuelle Rault , Emeline Saindoy , Sébastien Lachot , Mara Memoli , Nawa Hachem , Jean-Alain Martignoles , Valérie Gissot , Ludovic Suner , Emmanuel Gyan , Ollivier Legrand , Olivier Hérault , François Delhommeau

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Abstract

Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic cancers. Cytokines play an important role in the regulation of normal and pathologic hematopoiesis. A pro-inflammatory state, described in hematopoietic malignancies, may participate in clonal selection. To identify recurrent cytokine patterns according to AML ontogenic subtypes, we quantified the concentration of 49 cytokines in the bone marrow (BM) plasma from 124 patients with AML or myelodysplastic syndrome (MDS), and from 94 healthy volunteers. We confirmed a pro-inflammatory profile in MDS and AML, with increased concentrations of CXCL8, CXCL10 and IL-6. Only a few cytokines varied when comparing AML to MDS. De novo AML subtypes carry a specific cytokine pattern dominated by the increase in CLEC11A concentrations and the decrease in FLT3 ligand concentrations. These cytokines could participate in clonal selection in this subtype of AML while being less critical in the other AMLs - i.e. secondary-like or TP53-mutated subtypes.

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新发急性髓性白血病的特异性骨髓细胞因子模式

急性髓性白血病（AML）是一种异质性的造血肿瘤。细胞因子在正常和病理造血过程中起着重要的调节作用。在造血恶性肿瘤中描述的促炎状态可能参与克隆选择。为了根据AML的个体成因亚型确定复发性细胞因子的模式，我们量化了124例AML或骨髓增生异常综合征（MDS）患者和94名健康志愿者骨髓（BM）血浆中49种细胞因子的浓度。我们证实了MDS和AML的促炎特征，CXCL8、CXCL10和IL-6的浓度升高。在AML和MDS的比较中，只有少数细胞因子发生变化。新生AML亚型携带一种以CLEC11A浓度升高和FLT3配体浓度降低为主导的特异性细胞因子模式。这些细胞因子可以参与该亚型AML的克隆选择，而在其他AML（即继发性样AML或tp53突变亚型）中则不那么重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.