Factor XI levels and the risk of cardiovascular events: a systematic review and meta-analysis of case-control and cohort studies

IF 3.4 3区医学 Q2 HEMATOLOGY

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-07-01 DOI:10.1016/j.rpth.2025.102968

Wenchi Li , Qimin Ma , Wei Zhou , Feng Zhu

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Abstract

Background

The relationship between coagulation factor (F)XI and the risk of cardiovascular events has been investigated in several epidemiological studies, but the overall results remain inconclusive.

Objectives

The aim of this systematic review and meta-analysis of case-control and cohort studies was to evaluate the relationship between FXI and the risk of cardiovascular events. FXI levels in the general population and the risk of different cardiovascular events were the primary exposure and outcome, respectively.

Methods

Two independent reviewers (Li and Ma) screened all available literature to identify studies that met the inclusion criteria. A random or fixed-effects model was used, and heterogeneity was quantitatively tested by the I² statistic.

Results

A total of 16 original studies were included in the quantitative meta-analysis. The meta-analysis results of both case-control and cohort studies showed a positive correlation between FXI levels and the risk of cardiovascular events (odds ratio [OR], 1.77; 95% CI, 1.17-2.68; hazard ratio [HR], 1.34; 95% CI, 1.09-1.64). Subgroup analysis revealed a positive correlation between FXI levels and the risk of myocardial infarction (OR, 1.63; 95% CI, 1.02-2.60; HR, 2.53; 95% CI, 1.15-5.60), while there was no significant correlation between FXI levels and acute coronary syndrome or ischemic stroke (OR, 1.78; 95% CI, 0.40-7.82; HR, 1.15; 95% CI, 0.93-1.41).

Conclusion

Our findings support a positive correlation between FXI levels and the risk of cardiovascular events.

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因子XI水平与心血管事件风险：病例对照和队列研究的系统回顾和荟萃分析

一些流行病学研究已经调查了凝血因子(F)XI与心血管事件风险之间的关系，但总体结果仍不确定。本系统综述和荟萃分析的目的是评估FXI与心血管事件风险之间的关系。一般人群中的FXI水平和不同心血管事件的风险分别是主要暴露和结果。方法两位独立的审稿人（Li和Ma）筛选了所有可用的文献，以确定符合纳入标准的研究。采用随机或固定效应模型，采用I2统计量定量检验异质性。结果16项原始研究被纳入定量荟萃分析。病例对照和队列研究的荟萃分析结果均显示，FXI水平与心血管事件风险呈正相关(优势比[OR]， 1.77；95% ci, 1.17-2.68；风险比[HR]， 1.34；95% ci, 1.09-1.64)。亚组分析显示FXI水平与心肌梗死风险呈正相关(OR, 1.63；95% ci, 1.02-2.60；人力资源,2.53;95% CI, 1.15-5.60)，而FXI水平与急性冠状动脉综合征或缺血性卒中之间无显著相关性(or, 1.78；95% ci, 0.40-7.82；人力资源,1.15;95% ci, 0.93-1.41)。结论：我们的研究结果支持FXI水平与心血管事件风险呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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