The Association of VDR, CYP2R1, and GC Gene Polymorphisms, Dietary Intake, and BMI in Regulating Vitamin D Status.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Diseases (Basel, Switzerland) Pub Date : 2025-07-14 DOI:10.3390/diseases13070219

Carmina Mariana Stroia, Annamaria Pallag, Maria Vrânceanu, David de Lorenzo, Keith Anthony Grimaldi, Csaba Robert Pallag, Kinga Vindis, Diana Bei, Cristina Burlou-Nagy Fati, Timea Claudia Ghitea

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Abstract

Vitamin D plays a crucial role in bone health and immune function, with serum 25(OH)D levels influenced by genetic, dietary, and metabolic factors.

Background/objectives: This study investigated the impact of VDR rs731236, CYP2R1 rs10741657, and GC rs2282679 polymorphisms, body mass index (BMI), and dietary vitamin D intake on vitamin D status.

Methods: A total of 230 adults were classified into four BMI categories: normal weight (NW), overweight (OW), obesity class I (OB), and obesity class II/III (OP). Participants completed a Food Frequency Questionnaire (FFQ) and a 7-day Food Frequency Diary (FFD). Genotyping was performed using TaqMan assays, and serum 25(OH)D was quantified via spectrophotometry. Statistical analyses included ANOVA and multiple linear regression.

Results: The VDR rs731236 CC genotype, CYP2R1 rs10741657 AG/GG, and GC rs2282679 AC/CC were associated with lower serum vitamin D levels. A higher BMI was significantly correlated with reduced serum 25(OH)D (p < 0.001), with BMI emerging as the strongest predictor of vitamin D status. FFQ-based dietary intake showed a modest positive correlation with 25(OH)D (r = 0.47, p < 0.001).

Conclusions: BMI and genetic variants in VDR, CYP2R1, and GC significantly influence vitamin D metabolism. Personalized interventions addressing genetic predispositions and weight management may improve vitamin D status.

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VDR、CYP2R1和GC基因多态性、饮食摄入和BMI在调节维生素D状态中的关系

维生素D在骨骼健康和免疫功能中起着至关重要的作用，血清25(OH)D水平受遗传、饮食和代谢因素的影响。背景/目的：本研究探讨了VDR rs731236、CYP2R1 rs10741657和GC rs2282679多态性、体重指数（BMI）和膳食维生素D摄入量对维生素D状态的影响。方法：将230名成人分为正常体重（NW）、超重（OW）、肥胖I级（OB）和肥胖II/III级（OP） 4类。参与者完成了食物频率问卷（FFQ）和为期7天的食物频率日记（FFD）。TaqMan法进行基因分型，分光光度法测定血清25(OH)D。统计分析包括方差分析和多元线性回归。结果：VDR rs731236 CC基因型、CYP2R1 rs10741657 AG/GG、GC rs2282679 AC/CC与血清维生素D水平降低相关。较高的BMI与降低的血清25(OH)D显著相关（p < 0.001）， BMI成为维生素D状态的最强预测因子。以ffq为基础的膳食摄入量与25(OH)D呈中度正相关（r = 0.47, p < 0.001）。结论：BMI和VDR、CYP2R1和GC基因变异显著影响维生素D代谢。针对遗传倾向和体重管理的个性化干预可能改善维生素D状况。

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