Precision management of coronary in-stent restenosis.

IF 9 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Trends in Cardiovascular Medicine Pub Date : 2025-07-23 DOI:10.1016/j.tcm.2025.07.009

Travis M Wilson, Panagiotis M Sarris-Michopoulos, Riyan Siddiqui, Adeel Ahmed, Iqra Riaz, Giancarlo Licitra, Julia Ossi, Muzamil Khawaja, Alexander C Fanaroff, Akiko Maehara, Davide Capodanno, Chayakrit Krittanawong

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引用次数: 0

Abstract

The advent of percutaneous coronary intervention (PCI) and intracoronary stent development marked a pivotal milestone in the management of acute coronary syndromes, significantly reducing morbidity and mortality worldwide. However, despite ongoing advancements in stent technology, treatment modalities, and diagnostic tools, in-stent restenosis (ISR) remains a prevalent and challenging clinical issue, contributing substantially to the burden of cardiovascular disease. This review provides a comprehensive background of ISR, including its associated risk factors, pathophysiology, and current management strategies. By addressing gaps in ISR management, this review critically evaluates existing approaches and explores potential directions for advancing the field of interventional cardiology. Additionally, supporting data for these strategies are examined, and a diagnostic and treatment algorithm is proposed to guide complex clinical decision-making.

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冠状动脉支架内再狭窄的精准治疗。

经皮冠状动脉介入治疗（PCI）和冠状动脉内支架的出现标志着急性冠状动脉综合征治疗的关键里程碑，显著降低了全世界的发病率和死亡率。然而，尽管支架技术、治疗方式和诊断工具不断进步，支架内再狭窄（ISR）仍然是一个普遍且具有挑战性的临床问题，在很大程度上造成了心血管疾病的负担。本文综述了ISR的全面背景，包括其相关的危险因素、病理生理学和当前的管理策略。通过解决ISR管理的差距，本综述批判性地评估了现有的方法，并探索了推进介入心脏病学领域的潜在方向。此外，研究了这些策略的支持数据，并提出了一种诊断和治疗算法来指导复杂的临床决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cardiovascular Medicine 医学-心血管系统

CiteScore

18.70

自引率

2.20%

发文量

143

审稿时长

21 days

期刊介绍： Trends in Cardiovascular Medicine delivers comprehensive, state-of-the-art reviews of scientific advancements in cardiovascular medicine, penned and scrutinized by internationally renowned experts. The articles provide authoritative insights into various topics, encompassing basic mechanisms, diagnosis, treatment, and prognosis of heart and blood vessel disorders, catering to clinicians and basic scientists alike. The journal covers a wide spectrum of cardiology, offering profound insights into aspects ranging from arrhythmias to vasculopathies.