Comparing the Effect of 2 Artificial Tear Formulations on Daytime Ocular Surface Parameters After Orthokeratology Contact Lenses Wearing.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-07-25 DOI:10.1097/ICL.0000000000001207

Chih-Ying Lin, Wen-Ling Liao, Hui-Ju Lin, Chun-Chi Chiang, Yi-Yu Tsai, Ning-Yi Hsia, Yi-Ching Hsieh

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Abstract

Purpose: To compare the ocular comfort and tear film stability of low viscous and medium viscous lubricant eye drops in orthokeratology lens users.

Method: This is a prospective, two-arm, randomized, crossover trial. After a 7±2 day run-in and washout period, subjects were assigned to apply one of two eye drops to the orthokeratology lens bow every night before inserting their lenses. Low viscosity eye drops with sodium chloride 5.5 mg (AIM Artificial Tears, Aimedicine) and medium viscosity eye drops with 0.4% polyethylene glycol (Systane ULTRA Unit dose, Alcon) were used.

Results: The study included 40 subjects with a mean age of 10.40±2.64 years and an averaged spherical equivalent of-3.43±1.31 diopters. There were no significant differences in Ocular Surface Disease Index (OSDI), Schirmer,noncontact tear film break-up time (NiTBUT), corneal staining score (NEI), or topographic decentration between the two treatment groups.

Conclusion: Despite the disparity in viscosity, the difference in visual acuity, OSDI, Schirmer, NiTBUT, NEI, and topographic decentration failed to reach statistical significance. Therefore, wearing orthokeratology lenses with low or medium viscosity artificial tears did not significantly impact daily visual acuity, ocular surface parameters, or contact lens centration.

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比较两种人工泪液配方对角膜塑形隐形眼镜配戴后眼表参数的影响。

目的：比较低黏度和中黏度润滑剂滴眼液对角膜塑形镜使用者的眼舒适性和泪膜稳定性。方法：这是一项前瞻性、双组、随机、交叉试验。经过7±2天的磨合和冲洗期后，受试者被要求每晚在植入角膜塑形镜前将两种滴眼液中的一种滴在角膜塑形镜弓上。使用低粘度氯化钠滴眼液5.5 mg （AIM Artificial Tears, Aimedicine）和中粘度聚乙二醇滴眼液0.4% （Systane ULTRA Unit dose, Alcon）。结果：共纳入40例受试者，平均年龄10.40±2.64岁，平均视球体度数-3.43±1.31。两组患者在眼表疾病指数（OSDI）、Schirmer、非接触性泪膜破裂时间（NiTBUT）、角膜染色评分（NEI）、地形分散等方面均无显著差异。结论：尽管黏度存在差异，但视力、OSDI、Schirmer、NiTBUT、NEI、地形分散的差异均未达到统计学意义。因此，佩戴低粘度或中等粘度人工泪液的角膜塑形镜对日常视力、眼表参数或隐形眼镜集中度没有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye & Contact Lens-Science and Clinical Practice OPHTHALMOLOGY-

CiteScore

4.50

自引率

4.30%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Eye & Contact Lens: Science and Clinical Practice is the official journal of the Contact Lens Association of Ophthalmologists (CLAO), an international educational association for anterior segment research and clinical practice of interest to ophthalmologists, optometrists, and other vision care providers and researchers. Focusing especially on contact lenses, it also covers dry eye disease, MGD, infections, toxicity of drops and contact lens care solutions, topography, cornea surgery and post-operative care, optics, refractive surgery and corneal stability (eg, UV cross-linking). Peer-reviewed and published six times annually, it is a highly respected scientific journal in its field.