{"title":"Skeletal Health in Youth with Type 2 Diabetes.","authors":"Hanine AlArab, Anna Zenno, Melinda Pierce","doi":"10.1007/s11914-025-00925-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>This paper will discuss the impact of type 2 diabetes (T2D) on skeletal health in youth. We will review the myriad physiology and pathophysiology of diabetic bone fragility with a focus on several new findings in the past five years.</p><p><strong>Recent findings: </strong>T2D is associated with increased fracture risk despite normal or high bone mineral density. Evidence suggests T2D may adversely affect bone density acquisition during peak bone mass development. The pathophysiology involves low bone turnover, reduced unmineralized bone matrix, and increased collagen glycation, contributing to compromised bone strength. Recent findings from mouse models, Mendelian randomization, and human studies highlight the interplay between metabolic imbalances, genetic influences, cellular dysfunction, and treatment strategies. Bone fragility is a frequently underdiagnosed complication in youth with T2D. Early intervention in youth is crucial to prevent the progression of metabolic and osteopathic disturbances associated with diabetes that can impact long-term skeletal health.</p>","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":"23 1","pages":"33"},"PeriodicalIF":5.3000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Osteoporosis Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11914-025-00925-2","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Purpose of review: This paper will discuss the impact of type 2 diabetes (T2D) on skeletal health in youth. We will review the myriad physiology and pathophysiology of diabetic bone fragility with a focus on several new findings in the past five years.
Recent findings: T2D is associated with increased fracture risk despite normal or high bone mineral density. Evidence suggests T2D may adversely affect bone density acquisition during peak bone mass development. The pathophysiology involves low bone turnover, reduced unmineralized bone matrix, and increased collagen glycation, contributing to compromised bone strength. Recent findings from mouse models, Mendelian randomization, and human studies highlight the interplay between metabolic imbalances, genetic influences, cellular dysfunction, and treatment strategies. Bone fragility is a frequently underdiagnosed complication in youth with T2D. Early intervention in youth is crucial to prevent the progression of metabolic and osteopathic disturbances associated with diabetes that can impact long-term skeletal health.
期刊介绍：
This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis.
We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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