The effects of a long-duration intravenous infusion of detomidine, with and without vatinoxan, on equine energy metabolism and urine composition.

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia Pub Date : 2025-07-02 DOI:10.1016/j.vaa.2025.06.011

Noora Jantunen, Marja Raekallio, Bartlomiej Obrochta, Heidi Tapio, Luis Gracia Calvo, Rebecca Rivera Pöyhönen, Kati Hagman, Ninja Karikoski

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引用次数: 0

Abstract

Objective: To assess the effects of a 4 hour detomidine constant rate infusion (CRI) with and without a vatinoxan CRI on energy metabolism and urine composition.

Study design: Randomized, blinded, crossover study.

Animals: Eight Finnhorses, 587 (550-620) kg [median (range)] and 13 (4-16) years old.

Methods: Horses were administered an intravenous (IV) detomidine loading dose (0.01 mg kg^-1) followed by 240 minutes CRI (0.015 mg kg^-1 hour^-1) (DET) and the same detomidine protocol combined with an IV vatinoxan loading dose (0.15 mg kg^-1) and CRI (0.05 mg kg hour^-1) (DET+VAT). Blood samples for glucose, insulin, non-esterified fatty acid (sNEFA), and β-hydroxybutyrate (sBHB) concentrations were collected during and for 240 minutes after CRI. Urine samples for glucose and sodium concentrations were collected at the end of CRI. Data were analysed using repeated measures ANCOVA and Wilcoxon signed-rank test.

Results: Blood glucose concentrations were significantly higher during CRI with DET compared with DET+VAT (all p < 0.001). Median insulin concentration was significantly lower during CRI with DET compared with DET+VAT (p = 0.012-0.018) and peaked at the end of follow-up period. With DET+VAT CRI, sBHB and sNEFA were significantly higher compared with DET (p < 0.001-0.002, p < 0.001-0.007). Urination was more frequent during DET CRI than with DET+VAT (p = 0.020). Glucosuria was more profound with DET [6.3 (2.4-11.1) mmol L^-1] than with DET+VAT [0.1 (0.0-3.1) mmol L^-1] (p = 0.012). More sodium was excreted into urine with DET [49.0 (22-66) mmol L^-1] than with DET+VAT [27.0 (8-43) mmol L^-1] (p = 0.012).

Conclusions and clinical relevance: Vatinoxan alleviated detomidine-induced hypoinsulinaemia and hyperglycaemia and diminished urination frequency, glucosuria, and natriuresis during and after a 4 hour CRI. Vatinoxan may be beneficial during standing sedation with alpha2-adrenoceptor agonists.

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长时间静脉输注德托咪定对马能量代谢和尿液成分的影响。

目的：探讨替替诺散等速输注（CRI）和不输注替替诺散等速输注（CRI）对能量代谢和尿液组成的影响。研究设计：随机、盲法、交叉研究。动物：8匹芬兰马，587（550-620）公斤[中位数（范围）],13（4-16）岁。方法：给马静脉注射（IV）托托咪定负荷剂量（0.01 mg kg-1），随后240分钟进行CRI (0.015 mg kg-1小时-1)(DET)，同样的托托咪定方案联合静脉注射瓦替诺珊负荷剂量（0.15 mg kg-1）和CRI (0.05 mg kg-1小时-1)（DET+VAT）。血液中葡萄糖、胰岛素、非酯化脂肪酸（sNEFA）和β-羟基丁酸（shbhb）浓度在CRI期间和CRI后240分钟采集。在CRI结束时收集尿液葡萄糖和钠浓度样本。数据分析采用重复测量ANCOVA和Wilcoxon符号秩检验。结果：与DET+VAT相比，DET合并CRI时血糖浓度显著升高（p < 0.001）。与DET+VAT相比，DET联合CRI期间胰岛素浓度中位数显著降低（p = 0.012-0.018），并在随访结束时达到峰值。DET+VAT组CRI、shbhb、sNEFA均显著高于DET组（p < 0.001 ~ 0.002, p < 0.001 ~ 0.007）。DET CRI组尿频明显高于DET+VAT组（p = 0.020）。DET组[6.3 (2.4-11.1)mmol L-1]比DET+VAT组[0.1 (0.0-3.1)mmol L-1]血糖水平更高（p = 0.012）。DET组尿钠排泄量[49.0 (22-66)mmol -1]高于DET+VAT组[27.0 (8-43)mmol -1] （p = 0.012）。结论和临床意义：Vatinoxan减轻了德托咪定诱导的低胰岛素血症和高血糖，减少了4小时CRI期间和之后的排尿频率、血糖和尿钠。Vatinoxan在使用α 2-肾上腺素受体激动剂进行站立镇静时可能是有益的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary anaesthesia and analgesia 农林科学-兽医学

CiteScore

3.10

自引率

17.60%

发文量

审稿时长

97 days

期刊介绍： Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome: the basic sciences; pathophysiology of disease as it relates to anaesthetic management equipment intensive care chemical restraint of animals including laboratory animals, wildlife and exotic animals welfare issues associated with pain and distress education in veterinary anaesthesia and analgesia. Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.