Inner Ear Organoid as a Preclinical Model of Hearing Regeneration: Progress and Applications.

IF 4.5 3区医学 Q2 CELL & TISSUE ENGINEERING

Stem Cell Reviews and Reports Pub Date : 2025-07-25 DOI:10.1007/s12015-025-10941-5

Yingjie Wang, Mengyu Chen, Yiyin Pan, Xianxia Li, Xiangxin Lou

{"title":"Inner Ear Organoid as a Preclinical Model of Hearing Regeneration: Progress and Applications.","authors":"Yingjie Wang, Mengyu Chen, Yiyin Pan, Xianxia Li, Xiangxin Lou","doi":"10.1007/s12015-025-10941-5","DOIUrl":null,"url":null,"abstract":"<p><p>Hearing loss is one of the most common health problems and there is no suitable way to regenerate up to now. However, if the mechanism can be clearly clarified, physiological auditory regeneration may be a possibility. Organoids, artificially generated by pluripotent stem cells under three-dimensional (3D) culture system, are now considered attractive options for constructing different 3D models to study auditory regeneration and the potential mechanisms in vitro. Organoids are essentially miniature 3D models of specific organs or tissues, enabling scientists to investigate the causes of diseases, test new drugs, and explore personalized medicine within a controlled laboratory setting. Recent discoveries have demonstrated that stem cell-derived organoids can mimic environments in vivo and provide invaluable information for modeling cochlea micro-environment. In this paper, we will provide an overview of the progress achieved in inner ear organoids as a preclinical model, aiding our understanding and providing a more effective approach to addressing hearing loss.</p>","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.5000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stem Cell Reviews and Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12015-025-10941-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}

引用次数: 0

Abstract

Hearing loss is one of the most common health problems and there is no suitable way to regenerate up to now. However, if the mechanism can be clearly clarified, physiological auditory regeneration may be a possibility. Organoids, artificially generated by pluripotent stem cells under three-dimensional (3D) culture system, are now considered attractive options for constructing different 3D models to study auditory regeneration and the potential mechanisms in vitro. Organoids are essentially miniature 3D models of specific organs or tissues, enabling scientists to investigate the causes of diseases, test new drugs, and explore personalized medicine within a controlled laboratory setting. Recent discoveries have demonstrated that stem cell-derived organoids can mimic environments in vivo and provide invaluable information for modeling cochlea micro-environment. In this paper, we will provide an overview of the progress achieved in inner ear organoids as a preclinical model, aiding our understanding and providing a more effective approach to addressing hearing loss.

查看原文本刊更多论文

内耳类器官作为听力再生的临床前模型：进展与应用。

听力损失是最常见的健康问题之一，目前还没有合适的方法来恢复听力。然而，如果机制能够明确，生理性听觉再生可能是一种可能性。类器官是由多能干细胞在三维（3D）培养系统下人工生成的，目前被认为是构建不同3D模型来研究听觉再生及其体外潜在机制的有吸引力的选择。类器官本质上是特定器官或组织的微型3D模型，使科学家能够调查疾病的原因，测试新药，并在受控的实验室环境中探索个性化医疗。最近的发现表明，干细胞衍生的类器官可以模拟体内环境，为模拟耳蜗微环境提供了宝贵的信息。在本文中，我们将概述内耳类器官作为临床前模型的进展，以帮助我们理解并提供更有效的方法来解决听力损失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Stem Cell Reviews and Reports 医学-细胞生物学

CiteScore

9.30

自引率

4.20%

发文量

审稿时长

3 months

期刊介绍： The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.