Inflammatory Markers and their Relationship with Cognitive Function in Alzheimer's Disease and Mild Cognitive Impairment. Systematic Review and Meta-Analysis.

IF 3.9 4区医学 Q2 NEUROSCIENCES

NeuroMolecular Medicine Pub Date : 2025-07-25 DOI:10.1007/s12017-025-08866-w

Maria Fernanda Serna, Mildrey Mosquera, Herney Andrés García-Perdomo

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Abstract

This study estimates the association between blood levels of inflammatory markers and cognitive function in adults with Alzheimer's disease or mild cognitive impairment. A systematic review and meta-analysis were conducted to synthesize data from studies examining the relationship between blood levels of inflammatory markers and cognitive function in adults with Alzheimer's disease or mild cognitive impairment. The search strategy was applied to the Medline database through MEDLINE (OVID), WEB OF SCIENCE, SCOPUS, LILACS, and the Cochrane Central Register of Controlled Trials (CENTRAL). Studies were selected based on predefined criteria. We included 84 studies in the qualitative synthesis, with 75 incorporated into the meta-analysis. In blood samples, subjects with Alzheimer's disease showed significantly higher concentrations of IL-1β (mean difference 0.46 [95% CI: 0.35, 0.58]), IL-6 (3.41 [3.05, 3.78]), MCP-1 (26.20 [14.57, 37.82]), and TNF-α (6.68 [5.97, 7.39]), along with lower concentrations of IL-8 (- 1.46 [- 1.85, - 1.08]) and IL-10 (- 3.20 [- 4.21, - 2.20]). This systematic review and meta-analysis demonstrate significant alterations in inflammatory marker concentrations in blood samples of individuals with Alzheimer's disease and mild cognitive impairment. Elevated levels of IL-1β, IL-6, MCP-1, and TNF-α, alongside reduced IL-8 and IL-10 levels, suggest a robust inflammatory response associated with Alzheimer's disease.

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阿尔茨海默病和轻度认知障碍患者的炎症标志物及其与认知功能的关系系统评价与元分析。

这项研究估计了患有阿尔茨海默病或轻度认知障碍的成年人血液中炎症标志物水平与认知功能之间的关系。对患有阿尔茨海默病或轻度认知障碍的成人进行了系统回顾和荟萃分析，以综合研究炎症标志物血液水平与认知功能之间关系的数据。检索策略通过Medline （OVID）、WEB OF SCIENCE、SCOPUS、LILACS和Cochrane Central Register OF Controlled Trials （Central）应用于Medline数据库。研究是根据预先确定的标准选择的。我们在定性综合中纳入了84项研究，其中75项纳入了meta分析。在血液样本中，阿尔茨海默病患者的IL-1β（平均差异0.46 [95% CI: 0.35, 0.58]）、IL-6（3.41[3.05, 3.78]）、MCP-1（26.20[14.57, 37.82]）和TNF-α(6.68[5.97, 7.39])浓度显著升高，IL-8（- 1.46[- 1.85, - 1.08]）和IL-10（- 3.20[- 4.21, - 2.20]）浓度显著降低。本系统综述和荟萃分析表明，患有阿尔茨海默病和轻度认知障碍的个体血液样本中炎症标志物浓度有显著变化。IL-1β、IL-6、MCP-1和TNF-α水平的升高，以及IL-8和IL-10水平的降低，提示与阿尔茨海默病相关的强烈炎症反应。

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来源期刊

NeuroMolecular Medicine 医学-神经科学

CiteScore

7.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： NeuroMolecular Medicine publishes cutting-edge original research articles and critical reviews on the molecular and biochemical basis of neurological disorders. Studies range from genetic analyses of human populations to animal and cell culture models of neurological disorders. Emerging findings concerning the identification of genetic aberrancies and their pathogenic mechanisms at the molecular and cellular levels will be included. Also covered are experimental analyses of molecular cascades involved in the development and adult plasticity of the nervous system, in neurological dysfunction, and in neuronal degeneration and repair. NeuroMolecular Medicine encompasses basic research in the fields of molecular genetics, signal transduction, plasticity, and cell death. The information published in NEMM will provide a window into the future of molecular medicine for the nervous system.