The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer.

IF 7.6 2区医学 Q1 ONCOLOGY

NPJ Breast Cancer Pub Date : 2025-07-24 DOI:10.1038/s41523-025-00796-x

Matthew Fenton, Miki Yoneyama, Erik Wennerberg, Tom Lund, Andrew Tutt, Alan Melcher, Sandra Demaria, Navita Somaiah

引用次数: 0

Abstract

Hormone receptor-positive breast cancers are a diverse group of tumours, with only some responding well to immunotherapy. Alternative combination strategies such as radiotherapy present an exciting opportunity to improve immunotherapy responses. We review an intriguing overlap between the impact of oestrogen signalling and radiation on multiple signalling pathways and immune cells that may be exploited for therapeutic gains in breast cancer. This is synthesised with the pre-clinical data and clinical trial landscape supporting the use of combined radiation and immunotherapy to derive insights for future neo-adjuvant trial design.

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激素受体阳性乳腺癌的放射和免疫治疗尚未开发的潜力。

激素受体阳性乳腺癌是一组多种多样的肿瘤，只有一些对免疫治疗有良好反应。放疗等其他联合治疗策略为改善免疫治疗反应提供了令人兴奋的机会。我们回顾了雌激素信号和辐射对多种信号通路和免疫细胞的影响之间有趣的重叠，这些信号通路和免疫细胞可能被用于乳腺癌的治疗增益。这与临床前数据和临床试验景观相结合，支持使用联合放射和免疫治疗，以获得对未来新辅助试验设计的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Breast Cancer Medicine-Pharmacology (medical)

CiteScore

10.10

自引率

1.70%

发文量

122

审稿时长

9 weeks

期刊介绍： npj Breast Cancer publishes original research articles, reviews, brief correspondence, meeting reports, editorial summaries and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas, or the framing of new questions that need to be solved. Featured topics of the journal include imaging, immunotherapy, molecular classification of disease, mechanism-based therapies largely targeting signal transduction pathways, carcinogenesis including hereditary susceptibility and molecular epidemiology, survivorship issues including long-term toxicities of treatment and secondary neoplasm occurrence, the biophysics of cancer, mechanisms of metastasis and their perturbation, and studies of the tumor microenvironment.