Metabolomics in Breast Cancer: From Biomarker Discovery to Personalized Medicine.

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2025-06-23 DOI:10.3390/metabo15070428

Rosa Perestrelo, Catarina Luís

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引用次数: 0

Abstract

Breast cancer (BC) is a highly heterogeneous disease with distinct molecular subtypes, each exhibiting unique metabolic adaptations that drive tumor progression and therapy resistance. Metabolomics has emerged as a powerful tool for understanding cancer metabolism and identifying clinically relevant biomarkers guiding personalized therapeutic strategies. Advances in analytical techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy have enabled the identification of metabolic alterations associated with BC initiation, progression, and treatment response (dysregulated glycolysis, lipid metabolism, amino acid utilization, and redox homeostasis). This review aims to provide a comprehensive overview of the role of metabolomics in BC research, focusing on its applications in identifying metabolic biomarkers for early diagnosis, prognosis, and treatment response. It underscores how metabolomic profiling can unravel the metabolic adaptations of different BC subtypes, offering insights into tumor biology and mechanisms of therapy resistance. Ultimately, it highlights the promise of metabolomics in driving biomarker-guided diagnostics and the development of metabolically informed, personalized therapeutic strategies in the era of precision medicine.

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乳腺癌代谢组学：从生物标志物发现到个性化医疗。

乳腺癌（BC）是一种具有不同分子亚型的高度异质性疾病，每种亚型都表现出独特的代谢适应，从而驱动肿瘤进展和治疗耐药性。代谢组学已经成为了解癌症代谢和识别临床相关生物标志物指导个性化治疗策略的有力工具。分析技术的进步，如质谱（MS）和核磁共振（NMR）光谱学，已经能够识别与BC起始、进展和治疗反应相关的代谢改变（糖酵解、脂质代谢、氨基酸利用和氧化还原稳态失调）。本文旨在全面概述代谢组学在BC研究中的作用，重点介绍代谢组学在早期诊断、预后和治疗反应中识别代谢生物标志物的应用。它强调了代谢组学分析如何揭示不同BC亚型的代谢适应，为肿瘤生物学和治疗耐药机制提供见解。最终，它强调了代谢组学在推动生物标志物引导诊断和发展代谢信息方面的前景，以及精准医学时代的个性化治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.