Bioactive Peptides Derived from Tuna: Screening, Extraction, Bioactivity, and Mechanism of Action.

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2025-07-21 DOI:10.3390/md23070293

Jing-An Cheng, Di Wang, Gang Yu, Shengjun Chen, Zhenhua Ma, Ya Wei, Xue Zhao, Chunsheng Li, Yueqi Wang, Yi Zhang, Rong Cao, Yongqiang Zhao

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Abstract

Peptides play a crucial role in the development of pharmaceuticals and functional foods. Multiple studies have shown that natural bioactive peptides possess antioxidant, antihypertensive, anti-tumor, and anti-inflammatory activities. Marine bioactive peptides, especially those sourced from fish, constitute a substantial reservoir of these molecules. Although considerable research has been undertaken on fish-derived peptides, studies specifically concerning those from tuna are limited. Tuna, a marine fish of high nutritional value, generates substantial by-product waste during fishing and processing. Therefore, it is essential to conduct an evaluation of the advancements in study on tuna-derived active peptides and to offer a perspective on the direction of future investigations. This review integrates prospective bioactive peptides derived from tuna and reports contemporary strategies for their investigation, including extraction, purification, screening, identification, and activity evaluation procedures, including Yeast Surface Display (YSD) and molecular docking. This review seeks to promote the continued investigation and application of bioactive peptides derived from tuna.

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金枪鱼生物活性肽：筛选、提取、生物活性和作用机制。

多肽在药物和功能食品的开发中起着至关重要的作用。多项研究表明，天然生物活性肽具有抗氧化、抗高血压、抗肿瘤、抗炎等作用。海洋生物活性肽，特别是来源于鱼类的生物活性肽，构成了这些分子的大量储存库。尽管对鱼类衍生多肽进行了大量研究，但专门针对金枪鱼衍生多肽的研究还很有限。金枪鱼是一种营养价值很高的海洋鱼类，在捕捞和加工过程中会产生大量的副产品废物。因此，有必要对金枪鱼源性活性肽的研究进展进行评价，并对未来的研究方向进行展望。本文综述了来自金枪鱼的前瞻性生物活性肽，并报告了其研究的最新策略，包括提取、纯化、筛选、鉴定和活性评估程序，包括酵母表面显示（YSD）和分子对接。本文旨在促进金枪鱼生物活性肽的进一步研究和应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.