κ/ι-Carrageenan Blends in Plant Capsules: Achieving Harmony Between Mechanical and Disintegration Properties.

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2025-07-09 DOI:10.3390/md23070284

Zhenyu Liu, Chuqi He, Zhibin Yang, Qing Zhao, Yuting Dong, Jing Ye, Bingde Zheng, Ranjith Kumar Kankala, Xueqin Zhang, Meitian Xiao

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引用次数: 0

Abstract

The fast-disintegrating capsules rapidly disintegrate in various physiological environments, ensuring therapeutic efficacy. The formulation of plant-based capsules with balanced mechanical and fast disintegration characteristics continues to present technical challenges in pharmaceutical development. In this study, natural marine polysaccharides were utilized to achieve both rapid disintegration and excellent mechanical properties by combining κ-Carrageenan (κ-C) and ι-Carrageenan (ι-C). Additionally, the selection of KCl + NaCl mixed coagulants, along with the evaluation of their types, mass fractions, and ratios, enhanced the mechanical properties and transmittance of the capsules. FTIR analysis revealed that the membrane with a 5:5 κ-C/ι-C ratio formed hydrogen bonds, which were beneficial to its fast disintegration. SEM analysis revealed a dense microstructure in this formulation, contributing to its improved mechanical properties. Finally, this study hypothesizes that the disintegration behaviors of the capsules exhibited significant pH dependence, with ion exudation predominating in pH 1.2 and pH 7.0 media, while swelling dominated under pH 4.5 and pH 6.8 media. The prepared carrageenan blend-based capsules exhibited fast disintegration properties while maintaining excellent mechanical and barrier properties, thereby broadening the application of plant-based capsules in the field of medicine.

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植物胶囊中κ/ι-卡拉胶共混物：实现机械性能和崩解性能的和谐。

快速崩解胶囊在各种生理环境中迅速崩解，保证了治疗效果。具有平衡力学和快速崩解特性的植物性胶囊的配方仍然是药物开发中的技术挑战。本研究利用天然海洋多糖将κ-卡拉胶（κ-C）与ι-卡拉胶（ι-C）结合，实现了快速分解和优异的力学性能。此外，KCl + NaCl混合混凝剂的选择，以及它们的种类、质量分数和比例的评价，提高了胶囊的力学性能和透光率。FTIR分析表明，κ-C/ι-C比为5:5的膜形成了氢键，有利于膜的快速分解。SEM分析表明，该配方具有致密的微观结构，有助于提高其力学性能。最后，本研究假设胶囊的崩解行为表现出明显的pH依赖性，在pH 1.2和pH 7.0的介质中以离子渗出为主，而在pH 4.5和pH 6.8的介质中以溶胀为主。制备的卡拉胶共混型胶囊在保持优异的力学性能和阻隔性能的同时，具有快速崩解的特性，从而拓宽了植物性胶囊在医药领域的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.