Neonatal acute kidney injury and neurodevelopmental impairment: investigating associations in very low birthweight infants.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-07-25 DOI:10.1038/s41372-025-02370-6

Jeffrey E King, Jill C Newman, Olivia Kinsinger, Molly Mead, Megan D Rodgers, Amy L Ruddy-Humphries, Cassandra Coleman, David T Selewski, Heidi J Steflik

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引用次数: 0

Abstract

Objective: Associations between neonatal acute kidney injury (AKI) and neurodevelopmental impairment (NDI) remains understudied. We hypothesized AKI is associated with NDI in very low birthweight (VLBW) infants.

Study design: A single-center, retrospective cohort study of VLBW infants with and without AKI during hospitalization evaluated in developmental clinic at 18 to 35 months of age. Associations between AKI and NDI were examined using bivariate and multivariable generalized linear mixed modeling.

Result: Of 203 infants included, 64 (32%) experienced neonatal AKI and 76 (37%) developed NDI. The relative risk of NDI was significantly higher in those with AKI (RR 1.67, 95% CI 1.18-2.36; p < 0.01). In multivariable analysis, AKI was not an independent predictor of NDI (aRR 1.07, 95% CI 0.68-1.68; p = 0.77).

Conclusion: In bivariate analyses, AKI was a significant predictor of NDI. In a multivariable model, AKI was no longer an independent predictor of NDI. Further investigation is warranted.

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新生儿急性肾损伤和神经发育障碍：调查极低出生体重婴儿的关联。

目的：新生儿急性肾损伤（AKI）与神经发育障碍（NDI）之间的关系仍未得到充分研究。我们假设极低出生体重（VLBW）婴儿的AKI与NDI相关。研究设计：一项单中心、回顾性队列研究，在18 - 35月龄的发育临床评估住院期间有和没有AKI的VLBW婴儿。使用双变量和多变量广义线性混合模型检验AKI和NDI之间的关联。结果：203例新生儿中，64例（32%）发生新生儿AKI， 76例（37%）发生NDI。AKI患者NDI的相对风险显著高于AKI患者(RR 1.67, 95% CI 1.18-2.36；结论：在双变量分析中，AKI是NDI的重要预测因子。在多变量模型中，AKI不再是NDI的独立预测因子。有必要进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.