Genotype distribution and risk factors for human papillomavirus infection.

IF 3.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Journal of Gynecologic Oncology Pub Date : 2025-07-11 DOI:10.3802/jgo.2026.37.e7

Yanqing Shen, Zuwei Zhang, Shaole Shi, Caixia Zhang, Channi Wang, Ye Chen

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引用次数: 0

Abstract

Objective: To investigate the patterns of human papillomavirus (HPV) genotype distribution and identify high-risk factors for HPV infection, focusing on their etiological significance and potential public health implications.

Methods: This study enrolled 496 women from the Gynecology Outpatient Department of Wuhan Central Hospital between September 2021 and September 2024. Data were collected through medical records and questionnaire surveys to analyze the distribution characteristics of HPV infection. High-risk factors were evaluated using multivariate binary logistic regression analysis.

Results: HPV infection exhibited the highest infection rate among women ≤25 years (63.5%) and ≥49 years (55.0%), with the most common types of high-risk HPV being HPV52, 16, and 58. Protective factors included frequent condom use (odds ratio [OR]=0.580) and HPV vaccination (OR=0.564). High-risk factors included diabetes (OR=6.620), anxiety (OR=2.126), and low work intensity (OR=1.670).

Conclusion: This study demonstrated diabetes, anxiety, and low work intensity as significant risk factors for HPV infection, providing valuable etiological insights. Psychological assessments and diabetes management should be integrated into public health strategies for HPV prevention. Furthermore, multidisciplinary collaboration among gynecologists, psychologists, and endocrinologists, is also recommended to prevention and care efforts.

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人乳头瘤病毒感染的基因型分布及危险因素。

目的：调查人乳头瘤病毒（HPV）基因型分布规律，确定HPV感染的高危因素，重点探讨其病因学意义和潜在的公共卫生意义。方法：本研究于2021年9月至2024年9月在武汉市中心医院妇科门诊纳入496名妇女。通过病历和问卷调查收集资料，分析HPV感染的分布特征。采用多元二元logistic回归分析评估高危因素。结果：HPV感染率在≤25岁（63.5%）和≥49岁（55.0%）的女性中最高，高危型HPV52、16和58最常见。保护因素包括频繁使用避孕套（优势比[OR]=0.580）和HPV疫苗接种（OR=0.564）。高危因素包括糖尿病（OR=6.620）、焦虑（OR=2.126）和低工作强度（OR=1.670）。结论：本研究表明糖尿病、焦虑和低工作强度是HPV感染的重要危险因素，提供了有价值的病因学见解。心理评估和糖尿病管理应纳入预防HPV的公共卫生战略。此外，妇科医生、心理学家和内分泌学家之间的多学科合作也被推荐用于预防和护理工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gynecologic Oncology ONCOLOGY-OBSTETRICS & GYNECOLOGY

CiteScore

6.00

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Gynecologic Oncology (JGO) is an official publication of the Asian Society of Gynecologic Oncology. Abbreviated title is ''J Gynecol Oncol''. It was launched in 1990. The JGO''s aim is to publish the highest quality manuscripts dedicated to the advancement of care of the patients with gynecologic cancer. It is an international peer-reviewed periodical journal that is published bimonthly (January, March, May, July, September, and November). Supplement numbers are at times published. The journal publishes editorials, original and review articles, correspondence, book review, etc.