Smart hydrogels for in situ tissue drug delivery.

IF 12.1 2区医学 Q1 CELL BIOLOGY

Journal of Biomedical Science Pub Date : 2025-07-24 DOI:10.1186/s12929-025-01166-2

Shih-Ho Lin, Shan-Hui Hsu

引用次数: 0

Abstract

The application of smart hydrogels has become a booming research frontier in biomedical engineering. With the development of intelligent drug delivery systems, various biomimetic and biodegradable hydrogels are employed for localized drug delivery to tissues in the preclinical applications. These advanced materials are designed to match the diverse environmental and functional requirements of various tissue types and organs. This article discusses the attractive characteristics of smart hydrogels as delivery systems and reviews the design of a range of smart hydrogels, as well as the challenges of tissue-specific drug delivery, focusing on the last 5 years of frontward research.

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用于原位组织药物输送的智能水凝胶。

智能水凝胶的应用已成为生物医学工程领域蓬勃发展的研究前沿。随着智能给药系统的发展，各种仿生和可生物降解的水凝胶在临床前应用于组织局部给药。这些先进的材料旨在满足各种组织类型和器官的不同环境和功能要求。本文讨论了智能水凝胶作为递送系统的吸引人的特点，回顾了一系列智能水凝胶的设计，以及组织特异性药物递送的挑战，重点介绍了过去5年的前沿研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomedical Science 医学-医学：研究与实验

CiteScore

18.50

自引率

0.90%

发文量

审稿时长

1 months

期刊介绍： The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.