Magnesium for Prevention of New-onset Postoperative Atrial Fibrillation Following Cardiac Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart International Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI:10.17925/HI.2025.19.1.6

Sara Ghazizadeh, Alireza Malektojari, Zahra Javidfar, Shaghayegh Lahuti, Rahele Shokraei, Mohadeseh Zeinaee, Amirhosein Badele, Raziyeh Mirzadeh, Mitra Ashrafi, Fateme Afra, Mohammad Hamed Ersi, Marziyeh Heydari, Ava Ziaei, Zohreh Rezvani, Jasmine Mah, Dena Zeraatkar, Shahin Abbaszadeh, Tyler Pitre

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引用次数: 0

Abstract

Background: This meta-analysis article aimed to investigate the efficacy of magnesium in preventing new-onset postoperative atrial fibrillation (POAF).

Methods: We searched Medline, Embase, Web of Science and Cochrane Library without any language or publication date restriction up to August 2023. We included randomized controlled trials (RCTs) that enrolled adults undergoing cardiac surgery without a history of atrial fibrillation, exploring the effect of magnesium supplementation in preventing new-onset POAF. We assessed the risk of bias using the Cochrane Risk of Bias 2.0 (RoB 2.0) tool. We conducted a random-effects meta-analysis using R and assessed the certainty of the evidence.

Results: A total of 24 RCTs with 3,373 participants were included. We found that magnesium may reduce the risk of POAF compared to the control group (relative risk [RR]: 0.55; 95% confidence interval [CI]: 0.41, 0.74; low certainty). The subgroup analysis for trials with low/some concerns risk of bias showed that magnesium reduces the risk of new-onset POAF compared to control (RR: 0.70 [95% CI: 0.58, 0.84]; high certainty). Magnesium consumption had no significant effect on all-cause mortality (RR: 1.00 [95% CI: 0.34, 2.90]) or days of hospitalization (mean difference: -0.34 [95% CI: -0.94, 0.26]).

Conclusion: The evidence indicates that magnesium administration reduces the incidence of new-onset POAF.

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镁预防心脏手术后新发心房颤动：随机对照试验的系统回顾和荟萃分析

背景：本荟萃分析文章旨在探讨镁预防术后新发心房颤动（POAF）的疗效。方法：检索Medline、Embase、Web of Science和Cochrane Library，检索时间截止至2023年8月，无语言和出版日期限制。我们纳入了随机对照试验（RCTs），纳入了没有房颤病史的接受心脏手术的成年人，探讨镁补充剂在预防新发POAF中的作用。我们使用Cochrane risk of bias 2.0 （RoB 2.0）工具评估偏倚风险。我们使用R进行了随机效应荟萃分析，并评估了证据的确定性。结果：共纳入24项随机对照试验，共3373名受试者。我们发现，与对照组相比，镁可以降低POAF的风险(相对风险[RR]: 0.55；95%置信区间[CI]: 0.41, 0.74；低确定性)。低/部分偏倚风险试验的亚组分析显示，与对照组相比，镁可降低新发POAF的风险(RR: 0.70 [95% CI: 0.58, 0.84]；高确定性)。镁摄入对全因死亡率（RR: 1.00 [95% CI: 0.34, 2.90]）或住院天数（平均差异：-0.34 [95% CI: -0.94, 0.26]）无显著影响。结论：镁可降低新发POAF的发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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