To Combat Abnormal Cell Signaling Mediated Gastrointestinal Cancer by Therapeutic Modulation of Gut Microbiota Utilizing Prebiotics, Postbiotics, and Synbiotics.

Abstract

Background: Gastrointestinal (GI) cancer, a multifactorial disease, encompasses a group of malignancies that affect the gastrointestinal system. Being the second leading con-tributor to cancer-related deaths, GI cancer has become the burning issue of human health. Despite advances in treatment, the diverse nature of GI cancer indicates that a one-size-fits-all solution is not applicable.

Introduction: The gut microbiome can be therapeutically modulated by utilizing prebiotics, postbiotics, and synbiotics. Fermentation of prebiotics produces postbiotic compounds. To-gether the prebiotics and probiotics combination can be used as synbiotics which will be more beneficial.

Methods: PubMed and Google scholar search engine tools have been utilized to access ref-erences about the idea of this review to demonstrate the therapeutic modulation of microbiota, residing in the gut, which utilizes postbiotics, prebiotics and synbiotics for combating GI cancer.

Results: Exploration of prebiotics, postbiotics, and synbiotic compounds has given us de-tailed information about their contribution to combating GI cancer.

Conclusion: Intake of a combination of prebiotic, postbiotics and synbiotics can inhibit the growth of cancer cells, and activate protective and stress-resistant mechanisms in healthy cellswhich couldbe more beneficial than the administration of prebiotics or postbiotics or synbiotics alone in diminishing the risk of GI cancer.