Evaluation of the coalescent lung ultrasound score in rheumatoid arthritis-associated interstitial lung disease.

Abstract

Objective: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that can present with extra-articular findings. RA-associated interstitial lung disease (RA-ILD) is the most prominent extra-articular finding and is important because it contributes significantly to morbidity and mortality. The aim of this study was to determine the role of lung ultrasonography (LUS) in diagnosing RA-ILD and assessing the severity of involvement.

Method: The study included 69 patients aged 18 years and older who met the ACR/EULAR 2010 RA classification criteria. LUS was performed on the patients by an experienced, blinded specialist and the findings were compared with the high-resolution computed tomography (HRCT) Warrick score evaluated by an experienced radiologist.

Results: A statistically significant correlation was found between modified LUS scores and Warrick scores (r: 0.838). Among the patients screened with USG, USG ILD findings were detected in 35 patients with RA-ILD diagnosis (100%) and 1 of the 34 controls (2.9%). LUS was false positive in only 1 RA patient (p < 0.001).

Conclusion: In conclusion, USG can be considered as a method correlated with CT in assessing the degree of lung involvement. However, USG cannot distinguish malignant nodules, infectious disease or drug adverse reactions. HRCT is a reliable method for the primary differential diagnosis of lung involvement. According to our study, LUS can prolong the CT scan intervals in patients with stable clinical conditions and no obvious symptoms, thereby reducing unnecessary radiation exposure. Key Points • RA with interstitial lung disease • LUS in interstitial lung disease.