MFG-E8 Accelerates Abdominal Aortic Aneurysm Formation by Enhancing ERK MAPK/NOX4 Axis-Associated Oxidative Stress

IF 5.6 1区生物学 Q2 CELL BIOLOGY

Cell Proliferation Pub Date : 2025-07-24 DOI:10.1111/cpr.70104

Jie Xiao, Hai Hu, Minghui Zou, Chenhao Li, Dawei Deng, Xing Chen, Jinping Liu

引用次数: 0

Abstract

MFG-E8 promotes oxidative stress by upregulating NOX4 and activating the MAPK pathway, which increases ROS production and affects vascular smooth muscle cell (VSMC) apoptosis, thereby driving the progression of abdominal aortic aneurysm (AAA). Resveratrol can inhibit the expression and function of MFG-E8, reduce ROS generation, and lower the incidence and severity of AAA, making it a potential therapeutic agent for AAA.

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MFG-E8通过增强ERK MAPK/NOX4轴相关氧化应激加速腹主动脉瘤形成。

MFG-E8通过上调NOX4，激活MAPK通路，促进氧化应激，增加ROS的产生，影响血管平滑肌细胞（vascular smooth muscle cell， VSMC）凋亡，从而驱动腹主动脉瘤（腹主动脉瘤，AAA）的进展。白藜芦醇可以抑制MFG-E8的表达和功能，减少ROS的产生，降低AAA的发生率和严重程度，是潜在的AAA治疗剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Proliferation 生物-细胞生物学

CiteScore

14.80

自引率

2.40%

发文量

198

审稿时长

1 months

期刊介绍： Cell Proliferation Focus: Devoted to studies into all aspects of cell proliferation and differentiation. Covers normal and abnormal states. Explores control systems and mechanisms at various levels: inter- and intracellular, molecular, and genetic. Investigates modification by and interactions with chemical and physical agents. Includes mathematical modeling and the development of new techniques. Publication Content: Original research papers Invited review articles Book reviews Letters commenting on previously published papers and/or topics of general interest By organizing the information in this manner, readers can quickly grasp the scope, focus, and publication content of Cell Proliferation.