Resistance Training Improves Cognitive Function and Depression Without Changing BDNF Levels in People Living with HIV: a Randomized Controlled Clinical Trial.
IF 2.7 2区 医学Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
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引用次数: 0
Abstract
The increased life expectancy provided by Antiretroviral Therapy(ART) has led to the incidence of different comorbidities in people living with the Human Immunodeficiency Virus (HIV), especially comorbidities related to aging and mental health. Among these, cognitive impairment and depression increased in this population. Therefore, non-pharmacological strategies, such as physical exercise, have been studied to improve these outcomes. This study aimed to investigate the effects of eight weeks of resistance training(RT) on cognitive function and depression status in people with HIV. The sample consisted of 20 subjects (12 men and eight women), randomized in two groups: Control Group (CG, n = 9) and Training Group (TG, n = 11). Cognitive function (Stroop Test), depression status (Beck Depression Inventory- BDI), and plasma levels of Brain-Derived Neurotrophic Factor (BDNF) were assessed before and after the resistance training intervention. The results indicated thatRT was able to promote significant improvements in the cognitive domains and reduce symptoms of depression (ΔCG: 1.56 ± 2.46; ΔTG -3.18 ± 1.66, P > 0.001). Regarding BDNF, no significant change was observed (P > 0.05). In conclusion, eight weeks ofRT improves cognitive function and depression status in people with HIV, without changing the circulating BDNF levels (NCT03879993).
期刊介绍：
AIDS and Behavior provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews. provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews.5 Year Impact Factor: 2.965 (2008) Section ''SOCIAL SCIENCES, BIOMEDICAL'': Rank 5 of 29 Section ''PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH'': Rank 9 of 76
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