Metal-organic framework-based aptamer sensors for early diagnosis of breast cancer

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research Pub Date : 2025-07-23 DOI:10.1016/j.sbsr.2025.100855

Xiaoxia Yao , Wei Chen , Chi Zhang , Weixuan Shao , Mohammadreza Shokouhimehr , Can Guo , Zhengchun Liu

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引用次数: 0

Abstract

Breast cancer is among the most common neoplasms in women worldwide, and timely detection is important to ensure the greatest chance of survival. Metal-organic frameworks (MOFs) possess specific advantages for application in biosensors because they possess a high specific surface area, tunable pore structure, and excellent biocompatibility. This paper summarizes the research progress of MOF-based aptamer sensors for the early detection of biomarkers of breast cancer, including progress in single-biomarker and multiplex sensing and the use of various detection methods in aptamer-based sensors. Furthermore, it discusses novel component design, optimization of detection methods, and the expansion of clinical applications with MOF-based aptamer sensors. Functionalization and adjustment of MOFs through the introduction of new aptamers and techniques have improved sensor efficiency and provided new paths for early cancer diagnosis. Despite advancements, sensitivity, selectivity, and clinical feasibility concerns are areas that require more efforts.

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基于金属有机框架的适体传感器在乳腺癌早期诊断中的应用

乳腺癌是全世界女性中最常见的肿瘤之一，及时发现对于确保最大的生存机会至关重要。金属有机骨架（mof）具有高比表面积、可调节的孔结构和优异的生物相容性，在生物传感器中具有特殊的应用优势。本文综述了基于mof的适体传感器用于乳腺癌生物标志物早期检测的研究进展，包括单生物标志物和多生物标志物检测的进展以及各种检测方法在适配体传感器中的应用。此外，它还讨论了新的组件设计，检测方法的优化以及基于mof的适体传感器的临床应用的扩展。通过引入新的适配体和技术对mof进行功能化和调整，提高了传感器效率，为早期癌症诊断提供了新的途径。尽管取得了进步，但敏感性、选择性和临床可行性方面的问题仍需要更多的努力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensing and Bio-Sensing Research Engineering-Electrical and Electronic Engineering

CiteScore

10.70

自引率

3.80%

发文量

审稿时长

87 days

期刊介绍： Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies. The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.