Letter to the Editor: Impact of the COVID-19 pandemic on diagnosis and disease stage in HPV-positive oropharyngeal cancer: insights and future directions

Abstract

The recent publication titled “The Collateral Impact of the COVID-19 Pandemic on HPV-Positive Oropharyngeal Cancer Diagnosis” offers a timely investigation into how the pandemic influenced diagnostic delays and disease severity at presentation among patients with oropharyngeal cancer (OPC). Given that delays in diagnosis are closely associated with disease progression and poorer clinical outcomes, this study underscores the critical importance of timely detection. By analyzing and comparing patient cohorts from pre-pandemic and pandemic periods, the authors reveal shifts in diagnostic trends during a time of global healthcare disruption. The study’s robust sample size of 157 consecutive patients, coupled with the use of objective clinical metrics such as TNM staging and gross tumor volumes (GTVs), enhances the reliability of its findings. A notable increase in the proportion of patients presenting with advanced nodal disease and stage III cancer during the pandemic is reported. Although statistical significance was not reached for diagnostic or treatment delays, the clinical relevance of these trends remains clear. Approximately half of the delays were attributed to COVID-19-related factors, including reduced healthcare access and patient hesitancy. These findings have substantial implications for healthcare systems and policymakers. The authors advocate for targeted interventions, such as public awareness campaigns and virtual triage, to reduce delays in future health emergencies. Further multicenter and prospective studies are encouraged to explore regional variations and patient-reported outcomes. I commend the Oral Oncology editorial team and authors for their commitment to publishing impactful research that fosters innovation and improves patient care in head and neck oncology.