Altered breathing pattern and thoracic mobility in women with fibromyalgia: A case-control study

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain Pub Date : 2025-07-22 DOI:10.1016/j.jpain.2025.105508

Kent Jonsson , Andreas Pikwer , Erik MG Olsson , Magnus Peterson

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Abstract

The objective of this study was to investigate respiratory parameters, including minute ventilation, tidal volume, and respiratory rate, and the role of thoracic mobility in women with FM compared to healthy controls. This case-control study included 38 women with fibromyalgia and 44 age-matched healthy women. Respiratory rate was measured using a portable monitor and tidal volume was assessed through spirometry. The minute ventilation was calculated by multiplying tidal volume by respiratory rate. Thoracic mobility was evaluated by measuring chest expansion. Pressure pain threshold was assessed over paraspinal muscles between C7-T7 by algometry to evaluate pain sensitivity. Perceived stress was assessed using the questionnaire Perceived Stress Scale −10. Women with fibromyalgia exhibited significantly higher minute ventilation (p<0.032), respiratory rate (p<0.001), and lower tidal volume (p<0.001) compared to healthy controls. Thoracic mobility was reduced in participants with fibromyalgia. Group differences in minute ventilation disappeared when adjusting for perceived stress, suggesting a psychological influence on respiratory parameters. However, differences in respiratory rate and tidal volume were still significant. Fibromyalgia is associated with altered breathing function, including higher respiratory rate and lower tidal volume. Thoracic mobility and stress may contribute to these changes.

Perspective

Compared to healthy controls, women with fibromyalgia exhibit an altered breathing pattern which consists of higher minute ventilation due to increased respiratory rate. Reduced thoracic mobility and perceived stress may contribute to this condition. Including the respiratory system in the evaluation and treatment may optimize the effects of rehabilitation.

Trial registration number

ClinicalTrials.gov: NCT04098731.

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纤维肌痛患者的呼吸模式改变和胸部活动：一项病例对照研究

本研究的目的是研究呼吸参数，包括分钟通气量、潮气量和呼吸频率，以及与健康对照者相比，FM女性胸廓活动度的作用。这项病例对照研究包括38名患有纤维肌痛的女性和44名年龄匹配的健康女性。使用便携式监测仪测量呼吸频率，通过肺活量计评估潮气量。用潮气量乘以呼吸速率计算分钟通气量。通过测量胸部扩张来评估胸廓活动度。通过疼痛测量法评估C7-T7间棘旁肌的压痛阈值，以评估疼痛敏感性。感知压力采用问卷感知压力量表- 10进行评估。与健康对照组相比，患有纤维肌痛的女性表现出明显更高的分钟通气量（0.032）、呼吸频率（0.001）和更低的潮气量（0.001）。纤维肌痛患者的胸廓活动度降低。调整感知压力后，组间分钟通气量差异消失，提示心理因素对呼吸参数有影响。然而，呼吸频率和潮气量的差异仍然显著。纤维肌痛与呼吸功能改变有关，包括呼吸频率升高和潮气量降低。胸部活动和压力可能导致这些变化。与健康对照组相比，患有纤维肌痛的女性表现出呼吸模式的改变，其中包括由于呼吸频率增加而增加的分分钟换气。减少胸部活动和感知压力可能导致这种情况。将呼吸系统纳入评估和治疗可优化康复效果。试验注册号：clinicaltrials .gov: NCT04098731。

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来源期刊

Journal of Pain 医学-临床神经学

CiteScore

6.30

自引率

7.50%

发文量

441

审稿时长

42 days

期刊介绍： The Journal of Pain publishes original articles related to all aspects of pain, including clinical and basic research, patient care, education, and health policy. Articles selected for publication in the Journal are most commonly reports of original clinical research or reports of original basic research. In addition, invited critical reviews, including meta analyses of drugs for pain management, invited commentaries on reviews, and exceptional case studies are published in the Journal. The mission of the Journal is to improve the care of patients in pain by providing a forum for clinical researchers, basic scientists, clinicians, and other health professionals to publish original research.