Early postnatal management of neonatal RBC alloimmunization

IF 3.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2025-07-22 DOI:10.1016/j.bpobgyn.2025.102651

Debeer A MD, PhD , Vanhole C MD, PhD

引用次数: 0

Abstract

Hemolytic disease of the newborn (HDN) remains a significant clinical challenge in neonatal care. This review focuses on the early postnatal management of HDN and synthesizes current evidence-based recommendations to guide healthcare professionals in optimizing outcomes for affected neonates. Key areas of discussion include the diagnosis and monitoring of HDN, the management of hyperbilirubinemia, and the use of immunoglobulin therapy and exchange transfusion and transfusion policy. Practical challenges such as resource limitations, timely diagnosis, and the implementation of standardized protocols are highlighted. The review aims to provide a comprehensive overview of the latest evidence to support clinicians in making informed decisions in the management of HDN.

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新生儿红细胞同种异体免疫的产后早期处理

新生儿溶血病（HDN）仍然是新生儿护理的一个重大临床挑战。本文综述了HDN的早期产后管理，并综合了目前的循证建议，以指导卫生保健专业人员优化受影响新生儿的结果。讨论的关键领域包括HDN的诊断和监测、高胆红素血症的管理、免疫球蛋白治疗的使用、换血和输血政策。强调了资源限制、及时诊断和标准化协议实施等实际挑战。该综述旨在提供最新证据的全面概述，以支持临床医生在HDN管理方面做出明智的决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research Clinical Obstetrics & Gynaecology 医学-妇产科学

CiteScore

9.40

自引率

1.80%

发文量

113

审稿时长

54 days

期刊介绍： In practical paperback format, each 200 page topic-based issue of Best Practice & Research Clinical Obstetrics & Gynaecology will provide a comprehensive review of current clinical practice and thinking within the specialties of obstetrics and gynaecology. All chapters take the form of practical, evidence-based reviews that seek to address key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. Management will be described in practical terms so that it can be applied to the individual patient.