A trident-like multi-cationic photosensitizer with stabilized membrane camouflage for efficient tumor-targeted photodynamic therapy.

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-07-25 DOI:10.1039/d5cc02248g

Guofeng Yi,Jiayi Li,Qiqi Xu,Ying Wang,Chen Peng,Weijun Zhao,Cheng-Yun Wang

引用次数: 0

Abstract

We develop a unique trident-like multi-cationic photosensitizer (PS) with an acceptor-donor-acceptor (A-D-A) structure to enhance photodynamic therapy (PDT). The design minimizes PS leakage from membrane camouflaged nanoparticles (<1% in 24 h) via hydrophilic anchoring, while boosting ROS generation (13.8-fold higher 1O2 than Rose Bengal) through excited state optimization, thus significantly improving tumor-targeted PDT efficiency.

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具有稳定膜伪装的三叉状多阳离子光敏剂，用于有效的肿瘤靶向光动力治疗。

我们开发了一种独特的三叉状多阳离子光敏剂（PS），具有受体-供体-受体（a -d -a）结构，以增强光动力治疗（PDT）。该设计通过亲水性锚定最大限度地减少了膜修饰纳米颗粒的PS泄漏（24小时内<1%），同时通过激发态优化提高了ROS的生成（1O2比Rose Bengal高13.8倍），从而显著提高了肿瘤靶向PDT效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.