Enhanced Pickering Emulsification of Nano Titanium Dioxide via Sodium Lignosulfonate for Sunscreen Formulations.

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Langmuir Pub Date : 2025-07-25 DOI:10.1021/acs.langmuir.5c02855

Yue Cai,Yangyang Zhu,Haoguan Gui,Jiabao Fan,Junjie Nian,Cun Zhu,Yoojung Song,Sungbong Kye,Xiubo Zhao,Chao Yao

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引用次数: 0

Abstract

A high-energy ball milling strategy was developed to optimize nano titanium dioxide (nano-TiO2) through sodium lignosulfonate (SL)-mediated electrostatic surface modification. At 20 wt % nano-TiO2 and 5 wt % SL, the colloidal system achieved optimal stability with a sun protection factor (SPF) elevation from 15 to 17. Subsequent emulsion formulation with various aqueous phase to oil phase mass ratios (κ) yielded a Pickering emulsion at different pH values, demonstrating exceptional interfacial stabilization via nano-TiO2 and SL electrostatic assembly. The optimized TSL-4 emulsion (κ = 1:1, pH = 4) exhibited remarkable storage stability (keeping over 25 SPF value after 6 weeks of accelerated test) and thermal resilience (maintaining above 91% SPF retention through 10 freeze-thaw cycles.). Biological evaluations of TSL-4 (κ = 1:1) emulsion demonstrated no phototoxicity (irradiated vs nonirradiated viability difference < 2%), low cytotoxicity (90% HaCaT cell viability), and minimal cutaneous permeation (no nanoparticle accumulation in subcutaneous layers). The biomass-compound-modified nano-TiO2 system establishes a multifunctional sunscreen platform that synergistically integrates UV attenuation, colloidal stability, and biosafety.

查看原文本刊更多论文

木质素磺酸钠对防晒配方中纳米二氧化钛的强化酸洗乳化作用。

采用高能球磨策略，通过木质素磺酸钠（SL）介导的静电表面改性优化纳米二氧化钛（nano- tio2）。在20 wt %的纳米tio2和5 wt %的SL条件下，胶体体系达到了最佳的稳定性，防晒系数（SPF）从15到17。随后的乳液配方具有不同的水相与油相质量比（κ），得到了不同pH值下的Pickering乳液，通过纳米tio2和SL静电组装表现出优异的界面稳定性。优化后的TSL-4乳液（κ = 1:1, pH = 4）具有良好的贮藏稳定性（加速试验6周后SPF值保持在25以上）和热回弹性（10次冻融循环后SPF值保持在91%以上）。TSL-4 （κ = 1:1）乳剂的生物学评价显示无光毒性（辐照后与未辐照后活力差异< 2%），低细胞毒性（90% HaCaT细胞活力），皮肤渗透最小（皮下层无纳米颗粒积聚）。生物质-化合物修饰的纳米tio2体系建立了一个集紫外线衰减、胶体稳定性和生物安全性于一体的多功能防晒平台。

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来源期刊

Langmuir 化学-材料科学：综合

CiteScore

6.50

自引率

10.30%

发文量

1464

审稿时长

2.1 months

期刊介绍： Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).