Palladium-Catalyzed Silylation of 1-(2-Iodophenyl)-1H-indoles via Intramolecular C-H Activation.

Abstract

An efficient palladium-catalyzed C-H silylation of 1-(2-iodophenyl)-1H-indoles has been developed. The reaction exhibits an obvious electronic effect. This protocol uses Pd(OAc)2 as a catalyst with hexamethyldisilane as the trimethylsilyl source. The reaction exhibits good functional group tolerance and provides straightforward access to diverse silicon-containing indoles under relatively mild conditions.